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Tdark
ZNF446
Zinc finger protein 446

Protein Summary
Description
May be involved in transcriptional regulation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000594369
  • ENSP00000472802
  • ENSG00000083838
  • ENST00000610298
  • ENSP00000478778

Symbol
  • ZKSCAN20
  • ZSCAN30
  • ZSCAN52
  • ZKSCAN20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
histone modification site profile
0.9
tissue sample
0.63
cell type or tissue
0.62
transcription factor binding site profile
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.51   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.51   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (48)
ZNF232
Tdark
Family:  TF
Novelty:  0.68288358
p_int:  0.999996734
p_ni:  0.000003266
Score:  0.555
Data Source:  BioPlex,STRINGDB
ZNF397
Tbio
Family:  TF
Novelty:  0.60034816
p_int:  0.999989546
p_ni:  0.000010454
Score:  0.723
Data Source:  BioPlex,STRINGDB
ZNF24
Tbio
Family:  TF
Novelty:  0.02954446
p_int:  0.999984242
p_ni:  0.000015758
Score:  0.868
Data Source:  BioPlex,STRINGDB
DPH7
Tbio
Family:  Enzyme
Novelty:  0.05925085
p_int:  0.999653446
p_ni:  0.000346554
Score:  0.188
Data Source:  BioPlex,STRINGDB
ALDH3A1
Tchem
Family:  Enzyme
Novelty:  0.00592398
p_int:  0.99962118
p_ni:  0.000378806
p_wrong:  1.4e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
RGS3
Tbio
Novelty:  0.01749541
p_int:  0.998887982
p_ni:  0.001111961
p_wrong:  5.7e-8
Score:  0.202
Data Source:  BioPlex,STRINGDB
ZSCAN32
Tdark
Family:  TF
Novelty:  3.83392226
p_int:  0.99815171
p_ni:  0.001843544
p_wrong:  0.000004747
Score:  0.752
Data Source:  BioPlex,STRINGDB
ZNF483
Tdark
Family:  TF
Novelty:  0.39891191
p_int:  0.996335509
p_ni:  0.003664489
p_wrong:  2e-9
Score:  0.795
Data Source:  BioPlex,STRINGDB
ZNF18
Tdark
Family:  TF
Novelty:  0.31388256
p_int:  0.995892916
p_ni:  0.004107082
p_wrong:  2e-9
Score:  0.691
Data Source:  BioPlex,STRINGDB
ZKSCAN8
Tbio
Family:  TF
Novelty:  0.17881042
p_int:  0.995409582
p_ni:  0.004589185
p_wrong:  0.000001232
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
3
89.1
sex hormone-binding globulin measurement
3
2
3
78.7
mathematical ability
3
2
3
64
platelet crit
1
1
1
58.4
mean reticulocyte volume
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
89.1
sex hormone-binding globulin measurement
3
78.7
mathematical ability
3
64
platelet crit
1
58.4
mean reticulocyte volume
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 446
VGNC:2168
456350
Mouse
MGI:2442185
269870
Dog
zinc finger protein 446
VGNC:54391
100684106
Cow
zinc finger protein 446
VGNC:52289
615990
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 446
Mouse
Dog
zinc finger protein 446
Cow
zinc finger protein 446
Publication Statistics
PubMed Score 1.51
PubMed score by year
PubTator Score 1.44
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title