Tdark ZNF446 Zinc finger protein 446

Protein Summary

Description

May be involved in transcriptional regulation.

Uniprot Accession IDs

• Q9NWS9
• Q96AF5

Gene Name

• ZNF446

Ensembl ID

• ENST00000594369
• ENSP00000472802
• ENSG00000083838
• ENST00000610298
• ENSP00000478778

Symbol

• ZKSCAN20
• ZSCAN30
• ZSCAN52
• ZKSCAN20

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
histone modification site profile	0.9
tissue sample	0.63
cell type or tissue	0.62
transcription factor binding site profile	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.51   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 100   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.51   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (48)

Explore Interacting Targets

1 – 10 of 48

• See Interactions on String-DB

ZNF232

Tdark

Family:  TF

Novelty:  0.68288358

p_int:  0.999996734

p_ni:  0.000003266

Score:  0.555

Data Source:  BioPlex,STRINGDB

ZNF397

Tbio

Family:  TF

Novelty:  0.60034816

p_int:  0.999989546

p_ni:  0.000010454

Score:  0.723

Data Source:  BioPlex,STRINGDB

ZNF24

Tbio

Family:  TF

Novelty:  0.02954446

p_int:  0.999984242

p_ni:  0.000015758

Score:  0.868

Data Source:  BioPlex,STRINGDB

DPH7

Tbio

Family:  Enzyme

Novelty:  0.05925085

p_int:  0.999653446

p_ni:  0.000346554

Score:  0.188

Data Source:  BioPlex,STRINGDB

ALDH3A1

Tchem

Family:  Enzyme

Novelty:  0.00592398

p_int:  0.99962118

p_ni:  0.000378806

p_wrong:  1.4e-8

Score:  0.179

Data Source:  BioPlex,STRINGDB

RGS3

Tbio

Novelty:  0.01749541

p_int:  0.998887982

p_ni:  0.001111961

p_wrong:  5.7e-8

Score:  0.202

Data Source:  BioPlex,STRINGDB

ZSCAN32

Tdark

Family:  TF

Novelty:  3.83392226

p_int:  0.99815171

p_ni:  0.001843544

p_wrong:  0.000004747

Score:  0.752

Data Source:  BioPlex,STRINGDB

ZNF483

Tdark

Family:  TF

Novelty:  0.39891191

p_int:  0.996335509

p_ni:  0.003664489

p_wrong:  2e-9

Score:  0.795

Data Source:  BioPlex,STRINGDB

ZNF18

Tdark

Family:  TF

Novelty:  0.31388256

p_int:  0.995892916

p_ni:  0.004107082

p_wrong:  2e-9

Score:  0.691

Data Source:  BioPlex,STRINGDB

ZKSCAN8

Tbio

Family:  TF

Novelty:  0.17881042

p_int:  0.995409582

p_ni:  0.004589185

p_wrong:  0.000001232

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (3)

Reactome (3)

Gene expression (Transcription) (R-HSA-74160)

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Find Similar Targets

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5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (6)

Functions (4)

Components (2)

Find Similar Targets

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (13)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 13

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	3	3	3		89.1
sex hormone-binding globulin measurement	EFO_0004696	3	2	3		78.7
mathematical ability	EFO_0004875	3	2	3		64
platelet crit	EFO_0007985	1	1	1		58.4
mean reticulocyte volume	EFO_0010701	1	1	1		49.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 13

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	3		89.1
sex hormone-binding globulin measurement	EFO_0004696	3		78.7
mathematical ability	EFO_0004875	3		64
platelet crit	EFO_0007985	1		58.4
mean reticulocyte volume	EFO_0010701	1		49.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
DNA-binding
Isopeptide bond
Metal-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
cognitive function measurement
colorectal adenoma
colorectal cancer
heel bone mineral density
intelligence
mathematical ability
mean platelet volume
mean reticulocyte volume
platelet count
platelet crit

IDG Resources

No IDG generated resources found

Orthologs (4)

1 – 4 of 4

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	zinc finger protein 446	VGNC:2168	456350
Mouse	zinc finger protein 446	MGI:2442185	269870
Dog	zinc finger protein 446	VGNC:54391	100684106
Cow	zinc finger protein 446	VGNC:52289	615990

Species	Name	OMA	EggNOG	Inparanoid
Chimp	zinc finger protein 446
Mouse	zinc finger protein 446
Dog	zinc finger protein 446
Cow	zinc finger protein 446

Publication Statistics

PubMed Score 1.51

PubMed score by year

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PubTator Score 1.44

PubTator score by year

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Related Publications

Text Mined References (7)

GeneRif Annotations (1)

Items per page:

10

0 of 0

PMID	Year	Title