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Tdark
ZNF444
Zinc finger protein 444

Protein Summary
Description
Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter. This gene encodes a zinc finger protein which activates transcription of a scavenger receptor gene involved in the degradation of acetylated low density lipoprotein (Ac-LDL) (PMID: 11978792). This gene is located in a cluster of zinc finger genes on chromosome 19 at q13.4. A pseudogene of this gene is located on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337080
  • ENSP00000338860
  • ENSG00000167685
  • ENST00000592949
  • ENSP00000468069

Symbol
  • EZF2
  • ZSCAN17
  • EZF2
  • EZF-2
  • ZSCAN17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
histone modification site profile
0.76
transcription factor binding site profile
0.74
cell type or tissue
0.67
tissue sample
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.45   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.45   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
CCDC6
Tbio
Novelty:  0.00702098
p_int:  0.99999999
p_ni:  1e-8
Score:  0.524
Data Source:  BioPlex,STRINGDB
VWCE
Tbio
Novelty:  0.09328341
p_int:  0.999999412
p_ni:  5.88e-7
Data Source:  BioPlex
ZNF24
Tbio
Family:  TF
Novelty:  0.02954446
p_int:  0.999997917
p_ni:  0.000002083
Score:  0.763
Data Source:  BioPlex,STRINGDB
GPR156
Tdark
Family:  GPCR
Novelty:  0.39183023
p_int:  0.999979768
p_ni:  0.000020232
Data Source:  BioPlex
ZNF397
Tbio
Family:  TF
Novelty:  0.60034816
p_int:  0.999921513
p_ni:  0.000078487
Score:  0.735
Data Source:  BioPlex,STRINGDB
EFEMP1
Tbio
Novelty:  0.00574779
p_int:  0.999883278
p_ni:  0.000116722
Data Source:  BioPlex
SCAND1
Tbio
Novelty:  0.06863895
p_int:  0.999874743
p_ni:  0.000125218
p_wrong:  3.9e-8
Score:  0.735
Data Source:  BioPlex,STRINGDB
ZSCAN30
Tdark
Family:  TF
Novelty:  1.6056338
p_int:  0.999733414
p_ni:  0.000040735
p_wrong:  0.000225851
Score:  0.735
Data Source:  BioPlex,STRINGDB
ZKSCAN3
Tbio
Family:  TF
Novelty:  0.06833314
p_int:  0.999487232
p_ni:  0.00051268
p_wrong:  8.9e-8
Score:  0.689
Data Source:  BioPlex,STRINGDB
ZKSCAN4
Tbio
Family:  TF
Novelty:  0.33154485
p_int:  0.999165397
p_ni:  0.000834598
p_wrong:  5e-9
Score:  0.722
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
2
2
81.4
monocyte count
1
1
1
69.3
sex hormone-binding globulin measurement
5
1
5
64.4
monocyte percentage of leukocytes
1
1
1
52.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
81.4
monocyte count
1
69.3
sex hormone-binding globulin measurement
5
64.4
monocyte percentage of leukocytes
1
52.4
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 444
VGNC:11530
738565
Macaque
zinc finger protein 444
100424797
Mouse
MGI:1923365
72667
Rat
RGD:1304847
292569
Dog
zinc finger protein 444
VGNC:48729
611205
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 444
Macaque
zinc finger protein 444
Mouse
Rat
Dog
zinc finger protein 444
Publication Statistics
PubMed Score 3.45
PubMed score by year
PubTator Score 2.82
PubTator score by year
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Related Publications
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PMID
Year
Title