Tdark ZNF444 Zinc finger protein 444

Protein Summary

Description

Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter. This gene encodes a zinc finger protein which activates transcription of a scavenger receptor gene involved in the degradation of acetylated low density lipoprotein (Ac-LDL) (PMID: 11978792). This gene is located in a cluster of zinc finger genes on chromosome 19 at q13.4. A pseudogene of this gene is located on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q8N0Y2
• Q8TEQ9
• Q8WU35
• Q9NUU1

Gene Name

• ZNF444

Ensembl ID

• ENST00000337080
• ENSP00000338860
• ENSG00000167685
• ENST00000592949
• ENSP00000468069

Symbol

• EZF2
• ZSCAN17
• EZF2
• EZF-2
• ZSCAN17

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
histone modification site profile	0.76
transcription factor binding site profile	0.74
cell type or tissue	0.67
tissue sample	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.45   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 79   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.45   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (54)

Explore Interacting Targets

1 – 10 of 54

• See Interactions on String-DB

CCDC6

Tbio

Novelty:  0.00702098

p_int:  0.99999999

p_ni:  1e-8

Score:  0.524

Data Source:  BioPlex,STRINGDB

VWCE

Tbio

Novelty:  0.09328341

p_int:  0.999999412

p_ni:  5.88e-7

Data Source:  BioPlex

ZNF24

Tbio

Family:  TF

Novelty:  0.02954446

p_int:  0.999997917

p_ni:  0.000002083

Score:  0.763

Data Source:  BioPlex,STRINGDB

GPR156

Tdark

Family:  GPCR

Novelty:  0.39183023

p_int:  0.999979768

p_ni:  0.000020232

Data Source:  BioPlex

ZNF397

Tbio

Family:  TF

Novelty:  0.60034816

p_int:  0.999921513

p_ni:  0.000078487

Score:  0.735

Data Source:  BioPlex,STRINGDB

EFEMP1

Tbio

Novelty:  0.00574779

p_int:  0.999883278

p_ni:  0.000116722

Data Source:  BioPlex

SCAND1

Tbio

Novelty:  0.06863895

p_int:  0.999874743

p_ni:  0.000125218

p_wrong:  3.9e-8

Score:  0.735

Data Source:  BioPlex,STRINGDB

ZSCAN30

Tdark

Family:  TF

Novelty:  1.6056338

p_int:  0.999733414

p_ni:  0.000040735

p_wrong:  0.000225851

Score:  0.735

Data Source:  BioPlex,STRINGDB

ZKSCAN3

Tbio

Family:  TF

Novelty:  0.06833314

p_int:  0.999487232

p_ni:  0.00051268

p_wrong:  8.9e-8

Score:  0.689

Data Source:  BioPlex,STRINGDB

ZKSCAN4

Tbio

Family:  TF

Novelty:  0.33154485

p_int:  0.999165397

p_ni:  0.000834598

p_wrong:  5e-9

Score:  0.722

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (5)

Functions (3)

Components (1)

Processes (1)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet count	EFO_0004309	2	2	2		81.4
monocyte count	EFO_0005091	1	1	1		69.3
sex hormone-binding globulin measurement	EFO_0004696	5	1	5		64.4
monocyte percentage of leukocytes	EFO_0007989	1	1	1		52.4

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet count	EFO_0004309	2		81.4
monocyte count	EFO_0005091	1		69.3
sex hormone-binding globulin measurement	EFO_0004696	5		64.4
monocyte percentage of leukocytes	EFO_0007989	1		52.4

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Complete proteome
DNA-binding
Isopeptide bond
Metal-binding
Nucleus
Phosphoprotein
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
monocyte count
monocyte percentage of leukocytes
platelet count
sex hormone-binding globulin measurement

IDG Resources

No IDG generated resources found

Orthologs (6)

1 – 5 of 6

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	zinc finger protein 444	VGNC:11530	738565
Macaque	zinc finger protein 444		100424797
Mouse	zinc finger protein 444	MGI:1923365	72667
Rat	zinc finger protein 444	RGD:1304847	292569
Dog	zinc finger protein 444	VGNC:48729	611205

Species	Name	OMA	EggNOG	Inparanoid
Chimp	zinc finger protein 444
Macaque	zinc finger protein 444
Mouse	zinc finger protein 444
Rat	zinc finger protein 444
Dog	zinc finger protein 444

Publication Statistics

PubMed Score 3.45

PubMed score by year

Reset Zoom

PubTator Score 2.82

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (8)

GeneRif Annotations (2)

Items per page:

10

0 of 0

PMID	Year	Title