Protein Summary
Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter. This gene encodes a zinc finger protein which activates transcription of a scavenger receptor gene involved in the degradation of acetylated low density lipoprotein (Ac-LDL) (PMID: 11978792). This gene is located in a cluster of zinc finger genes on chromosome 19 at q13.4. A pseudogene of this gene is located on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
- ENST00000337080
- ENSP00000338860
- ENSG00000167685
- ENST00000592949
- ENSP00000468069
- EZF2
- ZSCAN17
- EZF2
- EZF-2
- ZSCAN17
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 0.85 | ||
histone modification site profile | 0.76 | ||
transcription factor binding site profile | 0.74 | ||
cell type or tissue | 0.67 | ||
tissue sample | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.45 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 79 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.45 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 79 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (54)
CCDC6
Novelty: 0.00702098
p_int: 0.99999999
p_ni: 1e-8
Score: 0.524
Data Source: BioPlex,STRINGDB
ZNF24
Family: TF
Novelty: 0.02954446
p_int: 0.999997917
p_ni: 0.000002083
Score: 0.763
Data Source: BioPlex,STRINGDB
GPR156
Family: GPCR
Novelty: 0.39183023
p_int: 0.999979768
p_ni: 0.000020232
Data Source: BioPlex
ZNF397
Family: TF
Novelty: 0.60034816
p_int: 0.999921513
p_ni: 0.000078487
Score: 0.735
Data Source: BioPlex,STRINGDB
SCAND1
Novelty: 0.06863895
p_int: 0.999874743
p_ni: 0.000125218
p_wrong: 3.9e-8
Score: 0.735
Data Source: BioPlex,STRINGDB
ZSCAN30
Family: TF
Novelty: 1.6056338
p_int: 0.999733414
p_ni: 0.000040735
p_wrong: 0.000225851
Score: 0.735
Data Source: BioPlex,STRINGDB
ZKSCAN3
Family: TF
Novelty: 0.06833314
p_int: 0.999487232
p_ni: 0.00051268
p_wrong: 8.9e-8
Score: 0.689
Data Source: BioPlex,STRINGDB
ZKSCAN4
Family: TF
Novelty: 0.33154485
p_int: 0.999165397
p_ni: 0.000834598
p_wrong: 5e-9
Score: 0.722
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (5)
Functions (3)
Components (1)
Processes (1)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
platelet count | 2 | 2 | 2 | 81.4 | |||||
monocyte count | 1 | 1 | 1 | 69.3 | |||||
sex hormone-binding globulin measurement | 5 | 1 | 5 | 64.4 | |||||
monocyte percentage of leukocytes | 1 | 1 | 1 | 52.4 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
platelet count | 2 | 81.4 | |||||
monocyte count | 1 | 69.3 | |||||
sex hormone-binding globulin measurement | 5 | 64.4 | |||||
monocyte percentage of leukocytes | 1 | 52.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | zinc finger protein 444 | VGNC:11530 | 738565 | |||||
Macaque | zinc finger protein 444 | 100424797 | ||||||
Mouse | MGI:1923365 | 72667 | ||||||
Rat | RGD:1304847 | 292569 | ||||||
Dog | zinc finger protein 444 | VGNC:48729 | 611205 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | zinc finger protein 444 | |||||
Macaque | zinc finger protein 444 | |||||
Mouse | ||||||
Rat | ||||||
Dog | zinc finger protein 444 | |||||
Publication Statistics
PubMed Score 3.45
PubMed score by year
PubTator Score 2.82
PubTator score by year
Related Publications
Text Mined References (8)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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