Protein Summary
Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds to the consensus site 5'-GCGCCC-3' in the promoter of PTCH1 (By similarity). This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein may negatively regulate transcription of target genes, including the hedgehog signaling pathway receptor patched 1, by interacting with histone deacetylases. Mutations in this gene may be associated with non-syndromic facial clefting in human patients. [provided by RefSeq, Jul 2016]
- ENST00000311048
- ENSP00000308578
- ENSG00000196705
- KIAA1969
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.69 | ||
molecular function | 0.63 | ||
microRNA | 0.59 | ||
biological process | 0.58 | ||
protein domain | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.05 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 65 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.05 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 65 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (13)
TYRP1
Family: Enzyme
Novelty: 0.00062138
p_int: 0.999812218
p_ni: 0.000187775
p_wrong: 7e-9
Score: 0.689
Data Source: BioPlex,STRINGDB
APP
Novelty: 0.00008964
p_int: 0.999136427
p_ni: 0.000008381
p_wrong: 0.000855191
Data Source: BioPlex
ICAM3
Novelty: 0.00213474
p_int: 0.953367488
p_ni: 4.1e-8
p_wrong: 0.046632471
Score: 0.416
Data Source: BioPlex,STRINGDB
CDX1
Family: TF
Novelty: 0.00815821
p_int: 0.846419207
p_ni: 0.000076757
p_wrong: 0.153504036
Score: 0.192
Data Source: BioPlex,STRINGDB
ZNF512
Family: TF
Novelty: 0.08783629
p_int: 0.82238248
p_ni: 0.00005003
p_wrong: 0.17756749
Data Source: BioPlex
Nearest Tclin Targets
Pathways (4)
Reactome (3)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | RNA Polymerase II Transcription | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
RNA Polymerase II Transcription | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (4)
Components (1)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs
Publication Statistics
PubMed Score 1.05
PubMed score by year
PubTator Score 0.67
PubTator score by year
Related Publications
Text Mined References (8)
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