Tdark ZNF416 Zinc finger protein 416

Protein Summary

Description

May be involved in transcriptional regulation.

Uniprot Accession IDs

• Q9BWM5
• Q9NWW8

Gene Name

• ZNF416

Ensembl ID

• ENST00000196489
• ENSP00000196489
• ENSG00000083817

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.85
cell line	0.64
histone modification site profile	0.61
protein domain	0.58
tissue	0.51

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.1   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 90   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.1   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (15)

Explore Interacting Targets

1 – 10 of 15

• See Interactions on String-DB

PGK2

Tbio

Family:  Kinase

Novelty:  0.00832045

p_int:  0.998807192

p_ni:  0.001192777

p_wrong:  3e-8

Score:  0.18

Data Source:  BioPlex,STRINGDB

TRIM39

Tbio

Family:  Enzyme

Novelty:  0.0837441

p_int:  0.998473512

p_ni:  0.001526488

Score:  0.201

Data Source:  BioPlex,STRINGDB

TUBA3C

Tchem

Novelty:  0.0187396

p_int:  0.995805425

p_ni:  0.004194575

Score:  0.15

Data Source:  BioPlex,STRINGDB

TRIM37

Tbio

Family:  Enzyme

Novelty:  0.02515451

p_int:  0.944394394

p_ni:  0.008096518

p_wrong:  0.047509087

Score:  0.776

Data Source:  BioPlex,STRINGDB

TRIM28

Tbio

Family:  Epigenetic

Novelty:  0.00778381

p_int:  0.865317346

p_ni:  0.134682654

Score:  0.914

Data Source:  BioPlex,STRINGDB

CENPB

Tbio

Novelty:  0.0036225

p_int:  0.822037292

p_ni:  0.177962708

Score:  0.204

Data Source:  BioPlex,STRINGDB

ZNF211

Tdark

Family:  TF

Novelty:  1.09151646

p_int:  0.813591902

p_ni:  0.000005985

p_wrong:  0.186402112

Score:  0.83

Data Source:  BioPlex,STRINGDB

PUS7L

Tdark

Family:  Enzyme

Novelty:  0.96856727

Score:  0.631

Data Source:  STRINGDB

NWD1

Tdark

Novelty:  0.28220226

Score:  0.602

Data Source:  STRINGDB

MAGEE2

Tdark

Novelty:  0.67122204

Score:  0.58

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (3)

KEGG (1)

Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (3)

Components (1)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	4	3	4		90.6
mean reticulocyte volume	EFO_0010701	1	1	1		62.1
balding measurement	EFO_0007825	1	1	1		24.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	4		90.6
mean reticulocyte volume	EFO_0010701	1		62.1
balding measurement	EFO_0007825	1		24.5

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
DNA-binding
Metal-binding
Nucleus
Reference proteome
Repeat
Transcription
Transcription regulation
Zinc
Zinc-finger

GWAS Trait Find Similar Targets

No Header	No Header
balding measurement
mean reticulocyte volume
red blood cell distribution width

IDG Resources

No IDG generated resources found

Orthologs (3)

1 – 3 of 3

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	zinc finger protein 416	VGNC:2176	469042
Macaque	zinc finger protein 416		708399
Rat	zinc finger protein 418	RGD:1311663	292548

Species	Name	OMA	EggNOG	Inparanoid
Chimp	zinc finger protein 416
Macaque	zinc finger protein 416
Rat	zinc finger protein 418

Publication Statistics

PubMed Score 1.10

PubMed score by year

Reset Zoom

Related Publications

Text Mined References (3)

Items per page:

10

0 of 0

PMID	Year	Title