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Tbio
ZNF408
Zinc finger protein 408

Protein Summary
Description
May be involved in transcriptional regulation. The protein encoded by this gene contains ten tandem zinc fingers and an N-terminal SET domain, so it is likely a DNA binding protein that interacts with other proteins. In adults, the encoded protein is expressed most highly in retina. Consequently, defects in this gene have been associated with familial exudative vitreoretinopathy (FEVR) and retinitis pigmentosa (RP). [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311764
  • ENSP00000309606
  • ENSG00000175213

Symbol
  • PFM14
  • PRDM17
  • EVR6
  • RP72
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.86
histone modification site profile
0.8
cell type or tissue
0.71
transcription factor
0.67
small molecule perturbation
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.32   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 162   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.32   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (88)
NINL
Tbio
Novelty:  0.00726815
p_int:  0.999999535
p_ni:  4.61e-7
p_wrong:  4e-9
Data Source:  BioPlex
FBN1
Tbio
Novelty:  0.00074957
p_int:  0.999998957
p_ni:  0.000001026
p_wrong:  1.7e-8
Score:  0.15
Data Source:  BioPlex,STRINGDB
SHCBP1
Tbio
Novelty:  0.09160318
p_int:  0.999994954
p_ni:  0.000005046
Data Source:  BioPlex
SMYD2
Tchem
Family:  Epigenetic
Novelty:  0.0192516
p_int:  0.999990082
p_ni:  0.000009918
Score:  0.222
Data Source:  BioPlex,STRINGDB
MIPOL1
Tbio
Novelty:  0.2456
p_int:  0.999988777
p_ni:  0.000011223
Data Source:  BioPlex
SEPHS2
Tdark
Family:  Enzyme
Novelty:  0.01657572
p_int:  0.999985569
p_ni:  0.000014333
p_wrong:  9.9e-8
Data Source:  BioPlex
EFEMP1
Tbio
Novelty:  0.00574779
p_int:  0.999981995
p_ni:  4.91e-7
p_wrong:  0.000017514
Data Source:  BioPlex
LRP1B
Tbio
Novelty:  0.01443405
p_int:  0.999981887
p_ni:  0.000018113
Data Source:  BioPlex
LTBP1
Tbio
Novelty:  0.00958396
p_int:  0.999979974
p_ni:  0.000020026
Data Source:  BioPlex
LZTS2
Tbio
Novelty:  0.09515452
p_int:  0.999976006
p_ni:  0.000023986
p_wrong:  8e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
2
1
1.9
98.2
bone density
3
4
4
94.1
high density lipoprotein cholesterol measurement
3
3
4
94
femoral neck bone mineral density
2
2
2
89
schizophrenia
2
2
0
1.1
76.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.9
98.2
bone density
4
94.1
high density lipoprotein cholesterol measurement
4
94
femoral neck bone mineral density
2
89
schizophrenia
0
1.1
76.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 408
VGNC:932
451157
Macaque
zinc finger protein 408
714213
Mouse
MGI:2685857
381410
Dog
zinc finger protein 408
VGNC:48720
100856561
Horse
zinc finger protein 408
VGNC:25318
100057443
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 408
Macaque
zinc finger protein 408
Mouse
Dog
zinc finger protein 408
Horse
zinc finger protein 408
Publication Statistics
PubMed Score 10.32
PubMed score by year
PubTator Score 5.16
PubTator score by year
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Related Publications
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PMID
Year
Title