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Tbio
ZNF398
Zinc finger protein 398

Protein Summary
Description
Function as a transcriptional activator. This gene encodes a member of the Kruppel family of C2H2-type zinc-finger transcription factor proteins. The encoded protein acts as a transcriptional activator. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described, but their full length sequence has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000426851
  • ENSP00000389972
  • ENSG00000197024
  • ENST00000475153
  • ENSP00000420418
  • ENST00000483892
  • ENSP00000418564
  • ENST00000491174
  • ENSP00000419391

Symbol
  • KIAA1339
  • ZER6
  • P51
  • P71
  • ZER6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.95
histone modification site profile
0.91
transcription factor binding site profile
0.84
protein domain
0.73
gene perturbation
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.21   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.21   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
ZNF282
Tdark
Family:  TF
Novelty:  0.32333465
p_int:  0.999999958
p_ni:  4.1e-8
Score:  0.825
Data Source:  BioPlex,STRINGDB
ELMO1
Tbio
Novelty:  0.01598587
p_int:  0.999999531
p_ni:  4.65e-7
p_wrong:  3e-9
Score:  0.519
Data Source:  BioPlex,STRINGDB
ZNF212
Tdark
Family:  TF
Novelty:  0.68902645
p_int:  0.999993342
p_ni:  3e-9
p_wrong:  0.000006655
Score:  0.869
Data Source:  BioPlex,STRINGDB
ZNF746
Tbio
Family:  TF
Novelty:  0.10426864
p_int:  0.999988868
p_ni:  0.000011132
Score:  0.674
Data Source:  BioPlex,STRINGDB
EFEMP1
Tbio
Novelty:  0.00574779
p_int:  0.999988712
p_ni:  0.000011278
p_wrong:  1e-8
Data Source:  BioPlex
FAM9B
Tdark
Novelty:  0.39508009
p_int:  0.999984152
p_ni:  0.000008742
p_wrong:  0.000007106
Data Source:  BioPlex
ZNF783
Tdark
Family:  TF
Novelty:  2.6332053
p_int:  0.999756774
p_ni:  2.31e-7
p_wrong:  0.000242995
Score:  0.622
Data Source:  BioPlex,STRINGDB
LRP4
Tbio
Novelty:  0.01336125
p_int:  0.999593958
p_ni:  0.000406037
p_wrong:  4e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
ZNF777
Tdark
Family:  TF
Novelty:  1.20195224
p_int:  0.99923214
p_ni:  0.00076786
Score:  0.798
Data Source:  BioPlex,STRINGDB
HIST2H2AB
Tbio
Novelty:  0.06772132
p_int:  0.867783503
p_ni:  0.132216459
p_wrong:  3.9e-8
Score:  0.17
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
2
3
89.4
eosinophil percentage of leukocytes
2
2
2
89
eosinophil percentage of granulocytes
1
1
1
82.6
neutrophil percentage of granulocytes
1
1
1
82.1
sum of eosinophil and basophil counts
1
1
1
78.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
89.4
eosinophil percentage of leukocytes
2
89
eosinophil percentage of granulocytes
1
82.6
neutrophil percentage of granulocytes
1
82.1
sum of eosinophil and basophil counts
1
78.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 398
VGNC:4576
472582
Mouse
MGI:1917856
272347
Rat
RGD:1562129
500108
Dog
zinc finger protein 398
VGNC:48718
100687206
Horse
zinc finger protein 398 [Source:HGNC Symbol;Acc:HGNC:18373]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 398
Mouse
Rat
Dog
zinc finger protein 398
Horse
zinc finger protein 398 [Source:HGNC Symbol;Acc:HGNC:18373]
Publication Statistics
PubMed Score 64.21
PubMed score by year
PubTator Score 28.76
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title