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Tbio
ZNF397
Zinc finger protein 397

Protein Summary
Description
Isoform 3 acts as a DNA-dependent transcriptional repressor. This gene encodes a protein with a N-terminal SCAN domain, and the longer isoform contains nine C2H2-type zinc finger repeats in the C-terminal domain. The protein localizes to centromeres during interphase and early prophase, and different isoforms can repress or activate transcription in transfection studies. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but their biological validity has not been determined. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261333
  • ENSP00000261333
  • ENSG00000186812
  • ENST00000330501
  • ENSP00000331577
  • ENST00000585800
  • ENSP00000466760
  • ENST00000591206
  • ENSP00000466317

Symbol
  • ZNF47
  • ZSCAN15
  • ZNF47
  • ZSCAN15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
kinase perturbation
0.76
protein domain
0.73
transcription factor binding site profile
0.71
microRNA
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.94   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.94   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
ZNF263
Tbio
Family:  TF
Novelty:  0.098799
p_int:  0.99999999
p_ni:  1e-8
Score:  0.693
Data Source:  BioPlex,STRINGDB
ZSCAN20
Tdark
Family:  TF
Novelty:  0.37441538
p_int:  0.999999987
p_ni:  1.3e-8
Score:  0.803
Data Source:  BioPlex,STRINGDB
ZNF232
Tdark
Family:  TF
Novelty:  0.68288358
p_int:  0.999999772
p_ni:  2.28e-7
Score:  0.696
Data Source:  BioPlex,STRINGDB
ZNF174
Tbio
Family:  TF
Novelty:  0.05970272
p_int:  0.999998554
p_ni:  0.000001326
p_wrong:  1.2e-7
Score:  0.812
Data Source:  BioPlex,STRINGDB
ZSCAN30
Tdark
Family:  TF
Novelty:  1.6056338
p_int:  0.999994043
p_ni:  0.000005947
p_wrong:  1.1e-8
Score:  0.832
Data Source:  BioPlex,STRINGDB
ZKSCAN4
Tbio
Family:  TF
Novelty:  0.33154485
p_int:  0.999990621
p_ni:  0.000009379
Score:  0.808
Data Source:  BioPlex,STRINGDB
ZNF446
Tdark
Family:  TF
Novelty:  0.80369039
p_int:  0.999989546
p_ni:  0.000010454
Score:  0.723
Data Source:  BioPlex,STRINGDB
P4HA1
Tchem
Family:  Enzyme
Novelty:  0.01624726
p_int:  0.999988933
p_ni:  0.000011066
p_wrong:  1e-9
Data Source:  BioPlex
ZKSCAN3
Tbio
Family:  TF
Novelty:  0.06833314
p_int:  0.999986581
p_ni:  0.000013419
Score:  0.812
Data Source:  BioPlex,STRINGDB
ZNF197
Tdark
Family:  TF
Novelty:  0.30062428
p_int:  0.999975552
p_ni:  0.000024425
p_wrong:  2.3e-8
Score:  0.812
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
3
3
68.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
68.2
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
zinc finger protein 397
714878
Mouse
MGI:1916506
69256
Rat
RGD:6504280
100909408
Dog
zinc finger protein 397
VGNC:49727
100686871
Horse
zinc finger protein 397
100052677
Species
Name
OMA
EggNOG
Inparanoid
Macaque
zinc finger protein 397
Mouse
Rat
Dog
zinc finger protein 397
Horse
zinc finger protein 397
Publication Statistics
PubMed Score 1.94
PubMed score by year
PubTator Score 1.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title