Tbio ZNF385A Zinc finger protein 385A

Protein Summary

Description

RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation. Zinc finger proteins, such as ZNF385A, are regulatory proteins that act as transcription factors, bind single- or double-stranded RNA, or interact with other proteins (Sharma et al., 2004 [PubMed 15527981]).[supplied by OMIM, Oct 2008]

Uniprot Accession IDs

• Q96PM9
• B2RDN5
• B4DKH2
• F1T0F1
• J3KNS3
• Q5VH53
• Q9H7R6
• Q9UFU3

Gene Name

• ZNF385A

Ensembl ID

• ENST00000338010
• ENSP00000338927
• ENSG00000161642
• ENST00000352268
• ENSP00000293385
• ENST00000394313
• ENSP00000377849
• ENST00000546970
• ENSP00000446913
• ENST00000551109
• ENSP00000449161
• ENST00000551771
• ENSP00000447162

Symbol

• HZF
• RZF
• ZNF385
• HZF
• RZF
• ZFP385
• ZNF385

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.92
transcription factor	0.76
molecular function	0.6
cell line	0.58
transcription factor binding site profile	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.55   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 111   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.55   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0