You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ZNF366
Zinc finger protein 366

Protein Summary
Description
Has transcriptional repression activity. Acts as corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318442
  • ENSP00000313158
  • ENSG00000178175

Symbol
  • DCSCRIPT
  • DC-SCRIPT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.75
tissue
0.69
molecular function
0.67
biological process
0.64
phenotype
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.3   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.3   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
UBE3A
Tbio
Family:  Enzyme
Novelty:  0.00149368
p_int:  0.999727739
p_ni:  0.000272261
Data Source:  BioPlex
KLHL15
Tbio
Novelty:  0.54712519
p_int:  0.837489159
p_ni:  0.162510812
p_wrong:  3e-8
Data Source:  BioPlex
CTBP1
Tbio
Novelty:  0.00243818
Score:  0.801
Data Source:  STRINGDB
ZNF367
Tbio
Family:  TF
Novelty:  0.27340562
Score:  0.794
Data Source:  STRINGDB
UBOX5
Tbio
Novelty:  0.37436118
Score:  0.732
Data Source:  STRINGDB
SLC35D2
Tbio
Family:  Transporter
Novelty:  0.1135727
Score:  0.725
Data Source:  STRINGDB
TMEM174
Tdark
Novelty:  0.40496536
Score:  0.724
Data Source:  STRINGDB
THNSL2
Tbio
Family:  Enzyme
Novelty:  0.01548751
Score:  0.714
Data Source:  STRINGDB
SLC35A3
Tbio
Family:  Transporter
Novelty:  0.02472244
Score:  0.704
Data Source:  STRINGDB
TMEM171
Tdark
Novelty:  2.00247773
Score:  0.691
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
4
4
95.6
monocyte count
2
2
2
89.5
myeloid white cell count
2
2
2
84.1
leukocyte count
2
2
2
81
lymphocyte percentage of leukocytes
1
2
2
79.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
4
95.6
monocyte count
2
89.5
myeloid white cell count
2
84.1
leukocyte count
2
81
lymphocyte percentage of leukocytes
2
79.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 366
VGNC:4235
471521
Macaque
zinc finger protein 366
100424526
Mouse
MGI:2178429
238803
Rat
RGD:2322904
100360041
Dog
zinc finger protein 366
VGNC:49720
487242
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 366
Macaque
zinc finger protein 366
Mouse
Rat
Dog
zinc finger protein 366
Publication Statistics
PubMed Score 14.30
PubMed score by year
PubTator Score 9.00
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title