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Tbio
ZNF318
Zinc finger protein 318

Protein Summary
Description
Isoform 2: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. Isoform 1: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361428
  • ENSP00000354964
  • ENSG00000171467
  • ENST00000605935
  • ENSP00000475748

Symbol
  • TZF
  • ZFP318
  • HRIHFB2436
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
microRNA
0.83
disease perturbation
0.79
histone modification site profile
0.73
kinase perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.15   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.15   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
RARRES1
Tbio
Family:  Enzyme
Novelty:  0.04701793
p_int:  0.999982067
p_ni:  0.000017933
Data Source:  BioPlex
CRYAA
Tchem
Novelty:  0.01914081
p_int:  0.999979959
p_ni:  0.000020041
Data Source:  BioPlex
SIRT6
Tchem
Family:  Epigenetic
Novelty:  0.00155366
p_int:  0.999686777
p_ni:  0.000313214
p_wrong:  9e-9
Data Source:  BioPlex
CDC16
Tbio
Novelty:  0.00916715
p_int:  0.999679799
p_ni:  0.0003202
p_wrong:  1e-9
Data Source:  BioPlex
NCAPH2
Tbio
Novelty:  0.12134933
p_int:  0.999665515
p_ni:  0.000334483
p_wrong:  2e-9
Data Source:  BioPlex
DISC1
Tbio
Novelty:  0.00183442
p_int:  0.99953391
p_ni:  0.00046609
Data Source:  BioPlex
ABTB2
Tdark
Novelty:  0.45729157
p_int:  0.998824645
p_ni:  0.001175355
Data Source:  BioPlex
IL17RA
Tclin
Novelty:  0.00416706
p_int:  0.998449367
p_ni:  0.001550629
p_wrong:  3e-9
Data Source:  BioPlex
C6orf141
Tdark
Novelty:  1.46022784
p_int:  0.996730864
p_ni:  0.003269135
p_wrong:  1e-9
Data Source:  BioPlex
BAG4
Tbio
Novelty:  0.02660607
p_int:  0.99314536
p_ni:  0.006854627
p_wrong:  1.3e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
4
5
90
testosterone measurement
4
4
4
90
BMI-adjusted hip circumference
2
9
9
86.4
age-related hearing impairment
2
2
1
8.8
85.3
urate measurement
2
2
3
72.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
5
90
testosterone measurement
4
90
BMI-adjusted hip circumference
9
86.4
age-related hearing impairment
1
8.8
85.3
urate measurement
3
72.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 318
VGNC:7946
462712
Macaque
zinc finger protein 318
100428675
Mouse
MGI:1889348
57908
Rat
RGD:1583221
685082
Dog
zinc finger protein 318
VGNC:48695
609493
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 318
Macaque
zinc finger protein 318
Mouse
Rat
Dog
zinc finger protein 318
Publication Statistics
PubMed Score 36.15
PubMed score by year
PubTator Score 4.87
PubTator score by year
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Related Publications
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PMID
Year
Title