Tdark ZNF317 Zinc finger protein 317

Protein Summary

Description

May function as a transcription factor. May play an important role in erythroid maturation and lymphoid proliferation.

Uniprot Accession IDs

• Q96PQ6
• Q6DCA9
• Q96PM0
• Q96PM1
• Q96PT2
• Q9HCI4

Gene Name

• ZNF317

Ensembl ID

• ENST00000247956
• ENSP00000247956
• ENSG00000130803
• ENST00000360385
• ENSP00000353554

Symbol

• KIAA1588

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.73
transcription factor binding site profile	0.71
cell line	0.59
cell type or tissue	0.59
microRNA	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.94   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 93   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.94   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (16)

Explore Interacting Targets

1 – 10 of 16

• See Interactions on String-DB

TUBA8

Tbio

Novelty:  0.06454549

p_int:  0.999570697

p_ni:  0.000429303

Score:  0.693

Data Source:  BioPlex,STRINGDB

WDR46

Tbio

Novelty:  0.19307408

p_int:  0.999367044

p_ni:  0.000632375

p_wrong:  5.81e-7

Data Source:  BioPlex

RPL7A

Tbio

Novelty:  0.01674027

p_int:  0.998080974

p_ni:  0.001917865

p_wrong:  0.000001161

Data Source:  BioPlex

GNL3

Tbio

Novelty:  0.00886703

p_int:  0.995056514

p_ni:  0.004808441

p_wrong:  0.000135045

Data Source:  BioPlex

RPL26L1

Tdark

Novelty:  0.75408617

p_int:  0.993029525

p_ni:  0.006970475

Score:  0.522

Data Source:  BioPlex,STRINGDB

RSBN1

Tbio

Novelty:  0.1955858

p_int:  0.990477753

p_ni:  0.009447349

p_wrong:  0.000074898

Score:  0.489

Data Source:  BioPlex,STRINGDB

PPAN

Tbio

Novelty:  0.01063709

p_int:  0.957380269

p_ni:  0.03678201

p_wrong:  0.005837721

Data Source:  BioPlex

RBM4

Tbio

Novelty:  0.02034191

p_int:  0.902394743

p_ni:  0.097605257

Data Source:  BioPlex

MRPL30

Tdark

Novelty:  1.03623556

p_int:  0.846763337

p_ni:  0.152927819

p_wrong:  0.000308844

Score:  0.175

Data Source:  BioPlex,STRINGDB

HECTD3

Tdark

Family:  Enzyme

Novelty:  2.20874654

p_int:  0.786362218

p_ni:  0.213637782

Score:  0.173

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (3)

KEGG (1)

Gene expression (Transcription) (R-HSA-74160)

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5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (3)

Components (1)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (1)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
suicide behaviour measurement	EFO_0006882	1	1	1		2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
suicide behaviour measurement	EFO_0006882	1		2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
DNA-binding
Metal-binding
Nucleus
Polymorphism
Reference proteome
Repeat
Transcription
Transcription regulation

GWAS Trait Find Similar Targets

No Header	No Header
suicide behaviour measurement

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	zinc finger protein 317	VGNC:11571	468709
Macaque	zinc finger protein 317		713200
Mouse	zinc finger protein 317	MGI:107775	244713
Rat	zinc finger protein 317	RGD:1565419	500950
Dog	zinc finger protein 317	VGNC:48694	484975

Species	Name	OMA	EggNOG	Inparanoid
Chimp	zinc finger protein 317
Macaque	zinc finger protein 317
Mouse	zinc finger protein 317
Rat	zinc finger protein 317
Dog	zinc finger protein 317

Publication Statistics

PubMed Score 0.94

PubMed score by year

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PubTator Score 1.00

PubTator score by year

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Related Publications

Text Mined References (8)

GeneRif Annotations (1)

Items per page:

10

0 of 0

PMID	Year	Title