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Tdark
ZNF282
Zinc finger protein 282

Protein Summary
Description
Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat. It recognizes the 5'-TCCACCCC-3' sequence as a core motif and exerts a strong repressive effect on HTLV-I LTR-mediated expression.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000479907
  • ENSP00000418840
  • ENSG00000170265
  • ENST00000610704
  • ENSP00000477841

Symbol
  • HUB1
  • HUB1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.74
protein domain
0.73
cell type or tissue
0.7
microRNA
0.69
transcription factor binding site profile
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.95   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.95   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (15)
RNH1
Tbio
Family:  Enzyme
Novelty:  0.00307468
p_int:  0.999999996
p_ni:  3e-9
Data Source:  BioPlex
ZNF398
Tbio
Family:  TF
Novelty:  0.01578856
p_int:  0.999999958
p_ni:  4.1e-8
Score:  0.825
Data Source:  BioPlex,STRINGDB
FGL2
Tbio
Novelty:  0.01108434
p_int:  0.999999675
p_ni:  3.25e-7
Score:  0.527
Data Source:  BioPlex,STRINGDB
ZNF212
Tdark
Family:  TF
Novelty:  0.68902645
p_int:  0.999983304
p_ni:  0.000016148
p_wrong:  5.48e-7
Score:  0.884
Data Source:  BioPlex,STRINGDB
TIMM8A
Tbio
Family:  Enzyme
Novelty:  0.00954602
p_int:  0.998932555
p_ni:  0.001065738
p_wrong:  0.000001707
Data Source:  BioPlex
TRIM28
Tbio
Family:  Epigenetic
Novelty:  0.00778381
Score:  0.947
Data Source:  STRINGDB
SART1
Tbio
Novelty:  0.00835627
Score:  0.75
Data Source:  STRINGDB
ELAVL1
Tchem
Novelty:  0.00110045
Score:  0.72
Data Source:  STRINGDB
CALCOCO1
Tbio
Novelty:  0.17497928
Score:  0.553
Data Source:  STRINGDB
WDR83
Tbio
Novelty:  0.11602568
Score:  0.539
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
2
3
89.4
eosinophil percentage of leukocytes
2
2
2
89
eosinophil percentage of granulocytes
1
1
1
82.6
neutrophil percentage of granulocytes
1
1
1
82.1
sum of eosinophil and basophil counts
1
1
1
78.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
89.4
eosinophil percentage of leukocytes
2
89
eosinophil percentage of granulocytes
1
82.6
neutrophil percentage of granulocytes
1
82.1
sum of eosinophil and basophil counts
1
78.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
zinc finger protein 282 [Source:HGNC Symbol;Acc:HGNC:13076]
Mouse
MGI:2141413
101095
Rat
RGD:1306278
297065
Opossum
zinc finger protein 282
100014558
Anole lizard
zinc finger protein 282
100555817
Species
Name
OMA
EggNOG
Inparanoid
Macaque
zinc finger protein 282 [Source:HGNC Symbol;Acc:HGNC:13076]
Mouse
Rat
Opossum
zinc finger protein 282
Anole lizard
zinc finger protein 282
Publication Statistics
PubMed Score 3.95
PubMed score by year
PubTator Score 7.98
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title