Tdark ZNF250 Zinc finger protein 250

Protein Summary

Description

May be involved in transcriptional regulation.

Uniprot Accession IDs

• P15622
• D3DWP1
• Q59HE9
• Q8N942
• Q96AH9

Gene Name

• ZNF250

Ensembl ID

• ENST00000292579
• ENSP00000292579
• ENSG00000196150
• ENST00000417550
• ENSP00000393442

Symbol

• ZNF647
• ZFP647
• ZNF647

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.94
histone modification site profile	0.89
disease perturbation	0.68
microRNA	0.66
small molecule perturbation	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.31   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 8   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.31   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 8   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (16)

Explore Interacting Targets

1 – 10 of 16

• See Interactions on String-DB

TRIM28

Tbio

Family:  Epigenetic

Novelty:  0.00778381

p_int:  0.999998171

p_ni:  0.000001829

Score:  0.944

Data Source:  BioPlex,STRINGDB

SPINT1

Tbio

Family:  Enzyme

Novelty:  0.00930324

p_int:  0.999816641

p_ni:  0.000061395

p_wrong:  0.000121963

Score:  0.685

Data Source:  BioPlex,STRINGDB

TPM2

Tbio

Novelty:  0.00406572

p_int:  0.983344452

p_ni:  0.016655546

p_wrong:  2e-9

Score:  0.245

Data Source:  BioPlex,STRINGDB

LTF

Tbio

Novelty:  0.00114254

p_int:  0.913844746

p_ni:  0.086155254

Score:  0.219

Data Source:  BioPlex,STRINGDB

ZC4H2

Tbio

Novelty:  0.04969464

Score:  0.686

Data Source:  STRINGDB

RPS7

Tbio

Novelty:  0.00745987

Score:  0.669

Data Source:  STRINGDB

ZNF428

Tdark

Novelty:  3.23887218

Score:  0.537

Data Source:  STRINGDB

FBXL6

Tdark

Novelty:  0.33416595

Score:  0.475

Data Source:  STRINGDB

WDR97

Tdark

Novelty:  11.62556618

Score:  0.469

Data Source:  STRINGDB

TMEM249

Tdark

Novelty:  11.31914894

Score:  0.468

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (3)

KEGG (1)

Gene expression (Transcription) (R-HSA-74160)

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Find Similar Targets

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5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (5)

Functions (4)

Components (1)

Find Similar Targets

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (1)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
type II diabetes mellitus	EFO_0001360	1	1	1		21.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
type II diabetes mellitus	EFO_0001360	1		21.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
DNA-binding
Isopeptide bond
Metal-binding
Nucleus
Reference proteome
Repeat
Transcription
Transcription regulation

GWAS Trait Find Similar Targets

No Header	No Header
type II diabetes mellitus

IDG Resources

No IDG generated resources found

Orthologs (4)

1 – 4 of 4

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	zinc finger protein 250		704805
Mouse	zinc finger protein 647	MGI:3052806	239546
Rat	zinc finger protein 647	RGD:1308203	362948
Dog	zinc finger protein 250	VGNC:48681	100683615

Species	Name	OMA	EggNOG	Inparanoid
Macaque	zinc finger protein 250
Mouse	zinc finger protein 647
Rat	zinc finger protein 647
Dog	zinc finger protein 250

Publication Statistics

PubMed Score 0.31

PubMed score by year

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PubTator Score 0.82

PubTator score by year

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Related Publications

Text Mined References (8)

Items per page:

10

0 of 0

PMID	Year	Title