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Tbio
ZNF24
Zinc finger protein 24

Protein Summary
Description
Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261332
  • ENSP00000261332
  • ENSG00000172466
  • ENST00000399061
  • ENSP00000382015
  • ENST00000589881
  • ENSP00000467655

Symbol
  • KOX17
  • ZNF191
  • ZSCAN3
  • KOX17
  • RSG-A
  • ZNF191
  • ZSCAN3
  • Zfp191
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
disease perturbation
0.93
virus perturbation
0.92
microRNA
0.86
histone modification site profile
0.84


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.59   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 235   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.59   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 235   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
ZNF444
Tdark
Family:  TF
Novelty:  0.21564163
p_int:  0.999997917
p_ni:  0.000002083
Score:  0.763
Data Source:  BioPlex,STRINGDB
ZSCAN32
Tdark
Family:  TF
Novelty:  3.83392226
p_int:  0.999993072
p_ni:  0.000006928
Score:  0.8
Data Source:  BioPlex,STRINGDB
ZNF446
Tdark
Family:  TF
Novelty:  0.80369039
p_int:  0.999984242
p_ni:  0.000015758
Score:  0.868
Data Source:  BioPlex,STRINGDB
ZNF232
Tdark
Family:  TF
Novelty:  0.68288358
p_int:  0.999981061
p_ni:  0.000018939
Score:  0.754
Data Source:  BioPlex,STRINGDB
SCAND1
Tbio
Novelty:  0.06863895
p_int:  0.999974465
p_ni:  0.000024663
p_wrong:  8.72e-7
Score:  0.864
Data Source:  BioPlex,STRINGDB
RGS3
Tbio
Novelty:  0.01749541
p_int:  0.999969179
p_ni:  0.000030821
Data Source:  BioPlex
ZSCAN1
Tbio
Family:  TF
Novelty:  0.0217244
p_int:  0.999889941
p_ni:  0.000110059
Score:  0.645
Data Source:  BioPlex,STRINGDB
ZSCAN20
Tdark
Family:  TF
Novelty:  0.37441538
p_int:  0.999852314
p_ni:  0.000147686
Score:  0.581
Data Source:  BioPlex,STRINGDB
ZNF396
Tbio
Family:  TF
Novelty:  0.95895478
p_int:  0.999779859
p_ni:  0.000220141
Score:  0.819
Data Source:  BioPlex,STRINGDB
MZF1
Tbio
Family:  TF
Novelty:  0.01193919
p_int:  0.999621222
p_ni:  0.000378778
Score:  0.415
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
3
3
60.4
wellbeing measurement
3
2
3
31.1
depressive symptom measurement
1
1
1
4.5
neuroticism measurement
1
1
1
4.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
60.4
wellbeing measurement
3
31.1
depressive symptom measurement
1
4.5
neuroticism measurement
1
4.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 24
VGNC:7821
455373
Macaque
zinc finger protein 24
100426673
Mouse
MGI:1929704
59057
Rat
RGD:727963
360204
Dog
zinc finger protein 24
VGNC:48680
480162
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 24
Macaque
zinc finger protein 24
Mouse
Rat
Dog
zinc finger protein 24
Publication Statistics
PubMed Score 40.59
PubMed score by year
PubTator Score 23.87
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title