Tbio ZNF24 Zinc finger protein 24

Protein Summary

Description

Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro.

Uniprot Accession IDs

• P17028
• O14754
• Q53YE4
• Q6ICR5
• Q8IZN4

Gene Name

• ZNF24

Ensembl ID

• ENST00000261332
• ENSP00000261332
• ENSG00000172466
• ENST00000399061
• ENSP00000382015
• ENST00000589881
• ENSP00000467655

Symbol

• KOX17
• ZNF191
• ZSCAN3
• KOX17
• RSG-A
• ZNF191
• ZSCAN3
• Zfp191

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.96
disease perturbation	0.93
virus perturbation	0.92
microRNA	0.86
histone modification site profile	0.84

Protein Classes

DTO Classes

Zinc Finger Protein 248

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.52   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 235   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.52   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 235   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0