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Tbio
ZNF219
Zinc finger protein 219

Protein Summary
Description
Transcriptional regulator (PubMed:14621294, PubMed:19549071). Recognizes and binds 2 copies of the core DNA sequence motif 5'-GGGGG-3' (PubMed:14621294). Binds to the HMGN1 promoter and may repress HMGN1 expression (PubMed:14621294). Regulates SNCA expression in primary cortical neurons (PubMed:19549071). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9 (By similarity). Plays a role in chondrocyte differentiation (By similarity). This gene is a member of the Kruppel-like zinc finger gene family. The encoded protein functions as a transcriptional repressor of the high mobility group nucleosome binding domain 1 protein, which is associated with transcriptionally active chromatin. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360947
  • ENSP00000354206
  • ENSG00000165804
  • ENST00000421093
  • ENSP00000392401
  • ENST00000451119
  • ENSP00000388558

Symbol
  • ZFP219
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.99
molecular function
0.96
transcription factor
0.83
small molecule perturbation
0.71
tissue sample
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.64   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.64   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (63)
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  1
Score:  0.606
Data Source:  BioPlex,STRINGDB
RBBP7
Tbio
Novelty:  0.01795364
p_int:  0.999999999
p_ni:  1e-9
Score:  0.825
Data Source:  BioPlex,STRINGDB
MTA3
Tbio
Family:  TF
Novelty:  0.02667635
p_int:  0.999999985
p_ni:  1.5e-8
Score:  0.699
Data Source:  BioPlex,STRINGDB
CHD5
Tbio
Family:  Epigenetic
Novelty:  0.06408395
p_int:  0.999999932
p_ni:  6.8e-8
Score:  0.841
Data Source:  BioPlex,STRINGDB
GATAD2B
Tbio
Family:  TF
Novelty:  0.056775
p_int:  0.999999873
p_ni:  1.27e-7
Score:  0.762
Data Source:  BioPlex,STRINGDB
MBD2
Tchem
Family:  TF
Novelty:  0.01209635
p_int:  0.999999868
p_ni:  1.32e-7
Score:  0.811
Data Source:  BioPlex,STRINGDB
MBD3L1
Tbio
Novelty:  0.11297566
p_int:  0.999999866
p_ni:  1.33e-7
p_wrong:  1e-9
Score:  0.828
Data Source:  BioPlex,STRINGDB
MBD3
Tbio
Family:  TF
Novelty:  0.04513502
p_int:  0.999999836
p_ni:  1.63e-7
p_wrong:  1e-9
Score:  0.57
Data Source:  BioPlex,STRINGDB
P3H2
Tbio
Family:  Enzyme
Novelty:  0.04237396
p_int:  0.999999801
p_ni:  1.98e-7
Score:  0.186
Data Source:  BioPlex,STRINGDB
MTA1
Tbio
Family:  TF
Novelty:  0.00464618
p_int:  0.99999966
p_ni:  3.4e-7
Score:  0.759
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Ectoderm Differentiation
WikiPathways
Ectoderm Differentiation
WikiPathways
Glycogen Synthesis and Degradation
Name
Explore in Pharos
Explore in Source
Ectoderm Differentiation
Ectoderm Differentiation
Glycogen Synthesis and Degradation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
1
3
77.1
testosterone measurement
2
1
2
76.3
hemoglobin measurement
2
1
2
74.8
red blood cell density measurement
1
1
1
69.4
platelet crit
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
77.1
testosterone measurement
2
76.3
hemoglobin measurement
2
74.8
red blood cell density measurement
1
69.4
platelet crit
1
54.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 219
VGNC:3285
465212
Macaque
zinc finger protein 219
707423
Mouse
MGI:1917140
69890
Rat
RGD:1359259
305848
Dog
zinc finger protein 219
VGNC:48675
100687980
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 219
Macaque
zinc finger protein 219
Mouse
Rat
Dog
zinc finger protein 219
Publication Statistics
PubMed Score 5.64
PubMed score by year
PubTator Score 5.14
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title