Tbio ZNF207 BUB3-interacting and GLEBS motif-containing protein ZNF207

Protein Summary

Description

Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187).

Uniprot Accession IDs

• O43670
• A8K6Y6
• E1P660
• E1P661
• E1P662
• Q53XS9
• Q96HW5
• Q9BUQ7
• BuGZ

Gene Name

• ZNF207

Ensembl ID

• ENST00000321233
• ENSP00000322777
• ENSG00000010244
• ENST00000394670
• ENSP00000378165
• ENST00000394673
• ENSP00000378168

Symbol

• BUGZ
• BuGZ
• hBuGZ

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	0.97
virus perturbation	0.94
molecular function	0.86
transcription factor binding site profile	0.84

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Bub3-interacting And Glebs Motif-containing Protein Znf207

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Bub3-interacting And Glebs Motif-containing Protein Znf207

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.58   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 307   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.58   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 307   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0