Tdark ZNF195 Zinc finger protein 195

Protein Summary

Description

May be involved in transcriptional regulation. This gene encodes a protein belonging to the Krueppel C2H2-type zinc-finger protein family. These family members are transcription factors that are implicated in a variety of cellular processes. This gene is located near the centromeric border of chromosome 11p15.5, next to an imprinted domain that is associated with maternal-specific loss of heterozygosity in Wilms' tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

Uniprot Accession IDs

• O14628
• A8K234
• B3KTK2
• B4DEL0
• C9JLY9
• L7MNK2
• Q0VAJ6
• Q658N8
• Q6ZNA9

Gene Name

• ZNF195

Ensembl ID

• ENST00000005082
• ENSP00000005082
• ENSG00000005801
• ENST00000343338
• ENSP00000344483
• ENST00000354599
• ENSP00000346613
• ENST00000399602
• ENSP00000382511
• ENST00000429541
• ENSP00000387998
• ENST00000438262
• ENSP00000414353
• ENST00000526601
• ENSP00000435828
• ENST00000528218
• ENSP00000436384
• ENST00000618467
• ENSP00000482411

Symbol

• ZNFP104
• HRF1
• ZNFP104

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.68
cell type or tissue	0.59
protein domain	0.58
histone modification site profile	0.57
disease perturbation	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.07   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 126   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.07   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (3)

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (21)

Explore Interacting Targets

1 – 10 of 21

• See Interactions on String-DB

TRIM28

Tbio

Family:  Epigenetic

Novelty:  0.00778381

p_int:  0.999979523

p_ni:  0.000020477

Score:  0.929

Data Source:  BioPlex,STRINGDB

RFPL4B

Tdark

Novelty:  2.42779597

p_int:  0.999672588

p_ni:  0.000327388

p_wrong:  2.4e-8

Score:  0.227

Data Source:  BioPlex,STRINGDB

L3MBTL1

Tchem

Family:  TF; Epigenetic

Novelty:  0.02321712

p_int:  0.999178558

p_ni:  0.000821383

p_wrong:  5.9e-8

Score:  0.219

Data Source:  BioPlex,STRINGDB

THSD4

Tbio

Novelty:  0.12898073

p_int:  0.997219492

p_ni:  0.001704095

p_wrong:  0.001076413

Score:  0.169

Data Source:  BioPlex,STRINGDB

C6orf141

Tdark

Novelty:  1.46022784

p_int:  0.996806155

p_ni:  0.003189236

p_wrong:  0.000004609

Data Source:  BioPlex

IL13RA2

Tbio

Novelty:  0.03465642

p_int:  0.996537693

p_ni:  0.00321101

p_wrong:  0.000251298

Data Source:  BioPlex

P4HA2

Tbio

Family:  Enzyme

Novelty:  0.02097718

p_int:  0.992997296

p_ni:  0.00690358

p_wrong:  0.000099123

Data Source:  BioPlex

PIAS4

Tbio

Family:  TF

Novelty:  0.01388547

p_int:  0.972856133

p_ni:  0.025523045

p_wrong:  0.001620822

Data Source:  BioPlex

DRC3

Tdark

Novelty:  0.99283468

p_int:  0.823453483

p_ni:  0.00244074

p_wrong:  0.174105776

Data Source:  BioPlex

F7

Tchem

Family:  Enzyme

Novelty:  0.0002521

Score:  0.8

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (3)

KEGG (1)

Gene expression (Transcription) (R-HSA-74160)

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Find Similar Targets

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5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (3)

Components (1)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
zinc ion binding	Non-traceable Author Statement (NAS)	UniProtKB
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (0)

No GWAS traits found

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Complete proteome
DNA-binding
Isopeptide bond
Metal-binding
Nucleus
Reference proteome
Repeat
Transcription

IDG Resources

No IDG generated resources found

Orthologs (2)

1 – 2 of 2

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	zinc finger protein 195	VGNC:12795	450964
Macaque	zinc finger protein 195		706915

Species	Name	OMA	EggNOG	Inparanoid
Chimp	zinc finger protein 195
Macaque	zinc finger protein 195

Publication Statistics

PubMed Score 4.07

PubMed score by year

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PubTator Score 9.80

PubTator score by year

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Related Publications

Text Mined References (9)

GeneRif Annotations (1)

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10

0 of 0

PMID	Year	Title