Tdark ZNF189 Zinc finger protein 189

Protein Summary

Description

May be involved in transcriptional regulation. Kruppel-like zinc finger proteins such as ZNF189 contain a conserved stretch of 7 amino acids that connects a variable number of DNA-binding zinc finger repeats of the cys(2)his(2) (C2H2) type (summarized by Odeberg et al., 1998 [PubMed 9653648]). Approximately 30% of human Kruppel-like zinc finger proteins contain an N-terminal Kruppel-associated box (KRAB) domain. The KRAB domain consists of approximately 75 amino acids that may be subdivided into an A box, which is present in every KRAB domain and is essential for transcriptional repression, and a B box, which is not always present.[supplied by OMIM, May 2010]

Uniprot Accession IDs

• O75820
• O75802
• Q5T7D7
• Q5T7D8
• Q5T7D9
• Q9UBL4
• Q9UPE9
• Q9UPF0
• Q9UPF1

Gene Name

• ZNF189

Ensembl ID

• ENST00000259395
• ENSP00000259395
• ENSG00000136870
• ENST00000339664
• ENSP00000342019
• ENST00000374861
• ENSP00000363995

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.88
cell type or tissue	0.73
tissue sample	0.73
transcription factor binding site profile	0.61
cell line	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.34   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 52   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.34   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 52   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (21)

Explore Interacting Targets

1 – 10 of 21

• See Interactions on String-DB

H2AFY2

Tbio

Novelty:  0.09948698

p_int:  0.999260127

p_ni:  0.000739694

p_wrong:  1.79e-7

Score:  0.159

Data Source:  BioPlex,STRINGDB

RPL7A

Tbio

Novelty:  0.01674027

p_int:  0.995686825

p_ni:  0.004221527

p_wrong:  0.000091648

Data Source:  BioPlex

NOP53

Tbio

Novelty:  0.00353077

p_int:  0.993941964

p_ni:  0.006021696

p_wrong:  0.00003634

Data Source:  BioPlex

DGCR8

Tbio

Novelty:  0.00271221

p_int:  0.989078141

p_ni:  0.010901045

p_wrong:  0.000020814

Data Source:  BioPlex

NOL12

Tbio

Novelty:  0.15925205

p_int:  0.988797442

p_ni:  0.011192583

p_wrong:  0.000009975

Score:  0.536

Data Source:  BioPlex,STRINGDB

HIST1H1A

Tbio

Novelty:  0.00123818

p_int:  0.947712446

p_ni:  0.009975997

p_wrong:  0.042311557

Score:  0.556

Data Source:  BioPlex,STRINGDB

ZNF2

Tbio

Family:  TF

Novelty:  0.01062543

p_int:  0.910723096

p_ni:  0.005650325

p_wrong:  0.083626579

Data Source:  BioPlex

RPL30

Tbio

Novelty:  0.0134194

p_int:  0.900088943

p_ni:  0.009618298

p_wrong:  0.090292759

Data Source:  BioPlex

PRR11

Tbio

Novelty:  0.05077483

p_int:  0.877967962

p_ni:  0.003023882

p_wrong:  0.119008156

Score:  0.524

Data Source:  BioPlex,STRINGDB

TRIM28

Tbio

Family:  Epigenetic

Novelty:  0.00778381

Score:  0.903

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (3)

KEGG (1)

Gene expression (Transcription) (R-HSA-74160)

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1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (6)

Functions (4)

Components (1)

Processes (1)

Find Similar Targets

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
DNA-binding transcription factor activity	Traceable Author Statement (TAS)	ProtInc
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
alkaline phosphatase measurement	EFO_0004533	4	4	4	9.9	97.9
C-reactive protein measurement	EFO_0004458	1	1	1		59
creatinine measurement	EFO_0004518	1	1	1		49.5
glomerular filtration rate	EFO_0005208	1	1	1		46.9

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
alkaline phosphatase measurement	EFO_0004533	4	9.9	97.9
C-reactive protein measurement	EFO_0004458	1		59
creatinine measurement	EFO_0004518	1		49.5
glomerular filtration rate	EFO_0005208	1		46.9

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
DNA-binding
Isopeptide bond
Metal-binding
Nucleus
Polymorphism
Reference proteome
Repeat
Transcription

GWAS Trait Find Similar Targets

No Header	No Header
alkaline phosphatase measurement
C-reactive protein measurement
creatinine measurement
glomerular filtration rate

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	zinc finger protein 189	VGNC:4906	472998
Macaque	zinc finger protein 189		713873
Mouse	zinc finger protein 189	MGI:2444707	230162
Rat	zinc finger protein 189	RGD:1306510	313219
Dog	zinc finger protein 189	VGNC:48671	474786

Species	Name	OMA	EggNOG	Inparanoid
Chimp	zinc finger protein 189
Macaque	zinc finger protein 189
Mouse	zinc finger protein 189
Rat	zinc finger protein 189
Dog	zinc finger protein 189

Publication Statistics

PubMed Score 3.34

PubMed score by year

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PubTator Score 3.00

PubTator score by year

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Related Publications

Text Mined References (11)

GeneRif Annotations (2)

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10

0 of 0

PMID	Year	Title