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Tdark
ZNF189
Zinc finger protein 189

Protein Summary
Description
May be involved in transcriptional regulation. Kruppel-like zinc finger proteins such as ZNF189 contain a conserved stretch of 7 amino acids that connects a variable number of DNA-binding zinc finger repeats of the cys(2)his(2) (C2H2) type (summarized by Odeberg et al., 1998 [PubMed 9653648]). Approximately 30% of human Kruppel-like zinc finger proteins contain an N-terminal Kruppel-associated box (KRAB) domain. The KRAB domain consists of approximately 75 amino acids that may be subdivided into an A box, which is present in every KRAB domain and is essential for transcriptional repression, and a B box, which is not always present.[supplied by OMIM, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259395
  • ENSP00000259395
  • ENSG00000136870
  • ENST00000339664
  • ENSP00000342019
  • ENST00000374861
  • ENSP00000363995
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
cell type or tissue
0.73
tissue sample
0.73
transcription factor binding site profile
0.61
cell line
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.34   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 52   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.34   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 52   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (21)
H2AFY2
Tbio
Novelty:  0.09948698
p_int:  0.999260127
p_ni:  0.000739694
p_wrong:  1.79e-7
Score:  0.159
Data Source:  BioPlex,STRINGDB
RPL7A
Tbio
Novelty:  0.01674027
p_int:  0.995686825
p_ni:  0.004221527
p_wrong:  0.000091648
Data Source:  BioPlex
NOP53
Tbio
Novelty:  0.00353077
p_int:  0.993941964
p_ni:  0.006021696
p_wrong:  0.00003634
Data Source:  BioPlex
DGCR8
Tbio
Novelty:  0.00271221
p_int:  0.989078141
p_ni:  0.010901045
p_wrong:  0.000020814
Data Source:  BioPlex
NOL12
Tbio
Novelty:  0.15925205
p_int:  0.988797442
p_ni:  0.011192583
p_wrong:  0.000009975
Score:  0.536
Data Source:  BioPlex,STRINGDB
HIST1H1A
Tbio
Novelty:  0.00123818
p_int:  0.947712446
p_ni:  0.009975997
p_wrong:  0.042311557
Score:  0.556
Data Source:  BioPlex,STRINGDB
ZNF2
Tbio
Family:  TF
Novelty:  0.01062543
p_int:  0.910723096
p_ni:  0.005650325
p_wrong:  0.083626579
Data Source:  BioPlex
RPL30
Tbio
Novelty:  0.0134194
p_int:  0.900088943
p_ni:  0.009618298
p_wrong:  0.090292759
Data Source:  BioPlex
PRR11
Tbio
Novelty:  0.05077483
p_int:  0.877967962
p_ni:  0.003023882
p_wrong:  0.119008156
Score:  0.524
Data Source:  BioPlex,STRINGDB
TRIM28
Tbio
Family:  Epigenetic
Novelty:  0.00778381
Score:  0.903
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Gene expression (Transcription) (R-HSA-74160)

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
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Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
4
4
4
9.9
97.9
C-reactive protein measurement
1
1
1
59
creatinine measurement
1
1
1
49.5
glomerular filtration rate
1
1
1
46.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
4
9.9
97.9
C-reactive protein measurement
1
59
creatinine measurement
1
49.5
glomerular filtration rate
1
46.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 189
VGNC:4906
472998
Macaque
zinc finger protein 189
713873
Mouse
MGI:2444707
230162
Rat
RGD:1306510
313219
Dog
zinc finger protein 189
VGNC:48671
474786
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 189
Macaque
zinc finger protein 189
Mouse
Rat
Dog
zinc finger protein 189
Publication Statistics
PubMed Score 3.34
PubMed score by year
PubTator Score 3.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title