Pharos : Target Details

Tdark

Protein Summary

Description

May be involved in transcriptional regulation.

Uniprot Accession IDs

Gene Name

ZNF18

Ensembl ID

ENST00000322748
ENSP00000315664
ENSG00000154957
ENST00000454073
ENSP00000391376
ENST00000580306
ENSP00000463471
ENST00000580613
ENSP00000462296

Symbol

HDSG1
KOX11
ZKSCAN6
ZNF535
HDSG1
KOX11
ZNF535
Zfp535
ZKSCAN6
ZSCAN38

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97

histone modification site profile	0.92

transcription factor binding site profile	0.64

transcription factor perturbation	0.61

tissue sample	0.57

Protein Classes

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.82 (req: < 5)

View Publications

Gene RIFs: 0 (req: <= 3)

Antibodies: 128 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.82 (req: >= 5)

Gene RIFs: 0 (req: > 3)

Antibodies: 128 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

No expression data found

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (16)

Explore Interacting Targets

1 – 10 of 16

See Interactions on String-DB

UHRF1

Tbio

Family: Epigenetic

Novelty: 0.00482565

p_int: 0.999964575

p_ni: 0.000035425

Score: 0.188

Data Source: BioPlex,STRINGDB

SCAND1

Tbio

Novelty: 0.06863895

p_int: 0.997067761

p_ni: 0.002932234

p_wrong: 5e-9

Score: 0.679

Data Source: BioPlex,STRINGDB

ZNF174

Tbio

Family: TF

Novelty: 0.05970272

p_int: 0.99691734

p_ni: 0.003054171

p_wrong: 0.000028489

Score: 0.808

Data Source: BioPlex,STRINGDB

ZNF446

Tdark

Family: TF

Novelty: 0.80369039

p_int: 0.995892916

p_ni: 0.004107082

p_wrong: 2e-9

Score: 0.691

Data Source: BioPlex,STRINGDB

ZNF24

Tbio

Family: TF

Novelty: 0.02954446

p_int: 0.985873922

p_ni: 0.014126078

Score: 0.817

Data Source: BioPlex,STRINGDB

ZNF483

Tdark

Family: TF

Novelty: 0.39891191

p_int: 0.922837308

p_ni: 0.027173097

p_wrong: 0.049989595

Score: 0.826

Data Source: BioPlex,STRINGDB

ZMYM6

Tdark

Novelty: 0.4933879

p_int: 0.915742653

p_ni: 0.084257343

p_wrong: 3e-9

Data Source: BioPlex

TRIM28

Tbio

Family: Epigenetic

Novelty: 0.00778381

Score: 0.903

Data Source: STRINGDB

NCKAP5L

Tdark

Novelty: 0.56142387

Score: 0.74

Data Source: STRINGDB

CDRT15

Tdark

Novelty: 1.16705127

Score: 0.634

Data Source: STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (3)

Reactome (3)

Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets

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1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160

Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436

Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160

Generic Transcription Pathway	1195 targets	R-HSA-212436

RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (3)

Components (1)

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Items per page:

1 – 3 of 3

GO Term	Evidence	Assigned by
DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB

metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (0)

No GWAS traits found

Find similar targets by:

UniProt Keyword

Find Similar Targets

No Header	No Header
Alternative splicing

Complete proteome

DNA-binding

Metal-binding

Nucleus

Polymorphism

Reference proteome

Repeat

Transcription

Transcription regulation

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID
Chimp	zinc finger protein 18	VGNC:9802	468395

Macaque	zinc finger protein 18		718115

Mouse	zinc finger with KRAB and SCAN domains 6	MGI:1289293	52712

Rat	zinc finger protein 18	RGD:1305130	303226

Dog	zinc finger protein 18	VGNC:48668	479505

Species	Name	OMA	EggNOG	Inparanoid
Chimp	zinc finger protein 18

Macaque	zinc finger protein 18

Mouse	zinc finger with KRAB and SCAN domains 6

Rat	zinc finger protein 18

Dog	zinc finger protein 18

Publication Statistics

PubMed Score 2.82

PubMed score by year

PubTator Score 2.76

PubTator score by year

Related Publications

Text Mined References (12)

Items per page:

0 of 0

PMID	Year	Title