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Tbio
ZMYND8
Protein kinase C-binding protein 1

Protein Summary
Description
May act as a transcriptional corepressor for KDM5D. Required for KDM5D-mediated down-regulation of diverse metastasis-associated genes; the function seems to involve the recognition of the dual histone signature H3K4me1-H3K14ac. Suppresses prostate cancer cell invasion. The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262975
  • ENSP00000262975
  • ENSG00000101040
  • ENST00000311275
  • ENSP00000312237
  • ENST00000352431
  • ENSP00000335537
  • ENST00000355972
  • ENSP00000348246
  • ENST00000360911
  • ENSP00000354166
  • ENST00000372023
  • ENSP00000361093
  • ENST00000396281
  • ENSP00000379577
  • ENST00000446994
  • ENSP00000396725
  • ENST00000458360
  • ENSP00000392964
  • ENST00000461685
  • ENSP00000418210
  • ENST00000471951
  • ENSP00000420095
  • ENST00000536340
  • ENSP00000439800
  • ENST00000540497
  • ENSP00000443086

Symbol
  • KIAA1125
  • PRKCBP1
  • RACK7
  • RACK7
  • PRKCBP1
  • PRO2893
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
protein domain
0.99
drug perturbation
0.96
disease perturbation
0.93
PubMedID
0.93


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.71   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.71   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0