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Tbio
ZMYND8
Protein kinase C-binding protein 1

Protein Summary
Description
May act as a transcriptional corepressor for KDM5D. Required for KDM5D-mediated down-regulation of diverse metastasis-associated genes; the function seems to involve the recognition of the dual histone signature H3K4me1-H3K14ac. Suppresses prostate cancer cell invasion. The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262975
  • ENSP00000262975
  • ENSG00000101040
  • ENST00000311275
  • ENSP00000312237
  • ENST00000352431
  • ENSP00000335537
  • ENST00000355972
  • ENSP00000348246
  • ENST00000360911
  • ENSP00000354166
  • ENST00000372023
  • ENSP00000361093
  • ENST00000396281
  • ENSP00000379577
  • ENST00000446994
  • ENSP00000396725
  • ENST00000458360
  • ENSP00000392964
  • ENST00000461685
  • ENSP00000418210
  • ENST00000471951
  • ENSP00000420095
  • ENST00000536340
  • ENSP00000439800
  • ENST00000540497
  • ENSP00000443086

Symbol
  • KIAA1125
  • PRKCBP1
  • RACK7
  • RACK7
  • PRKCBP1
  • PRO2893
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
protein domain
0.99
drug perturbation
0.96
disease perturbation
0.93
PubMedID
0.93


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.26   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.26   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (74)
P4HA3
Tbio
Family:  Enzyme
Novelty:  0.03832564
p_int:  0.999999958
p_ni:  4.2e-8
Score:  0.182
Data Source:  BioPlex,STRINGDB
CSNK2B
Tbio
Family:  Kinase
Novelty:  0.00152367
p_int:  0.999999862
p_ni:  1.38e-7
Data Source:  BioPlex
CSNK2A2
Tchem
Family:  Kinase
Novelty:  0.00231447
p_int:  0.999999602
p_ni:  3.98e-7
Data Source:  BioPlex
LLGL2
Tbio
Novelty:  0.07084531
p_int:  0.999998388
p_ni:  0.000001612
Data Source:  BioPlex
KCTD17
Tbio
Novelty:  0.12105733
p_int:  0.99999802
p_ni:  0.00000198
Data Source:  BioPlex
GATAD2A
Tbio
Novelty:  0.05599551
p_int:  0.999996614
p_ni:  0.000003386
Score:  0.725
Data Source:  BioPlex,STRINGDB
ZNF408
Tbio
Family:  TF
Novelty:  0.10649477
p_int:  0.999862512
p_ni:  0.000137488
Data Source:  BioPlex
TSPYL1
Tbio
Novelty:  0.06381144
p_int:  0.994782981
p_ni:  0.005217004
p_wrong:  1.6e-8
Score:  0.22
Data Source:  BioPlex,STRINGDB
APOD
Tbio
Novelty:  0.0031899
p_int:  0.907330299
p_ni:  0.092535296
p_wrong:  0.000134405
Data Source:  BioPlex
INTS6
Tbio
Novelty:  0.02680242
Score:  0.993
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
1
3
85.6
waist-hip ratio
2
1
2
68.6
wellbeing measurement
3
3
3
62.8
coffee consumption measurement
2
2
2
60.8
hip circumference
2
2
2
55.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
85.6
waist-hip ratio
2
68.6
wellbeing measurement
3
62.8
coffee consumption measurement
2
60.8
hip circumference
2
55.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger MYND-type containing 8
VGNC:10065
458306
Mouse
MGI:1918025
228880
Rat
RGD:1309544
296374
Dog
zinc finger MYND-type containing 8
VGNC:48654
477252
Horse
zinc finger MYND-type containing 8
VGNC:25257
100056807
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger MYND-type containing 8
Mouse
Rat
Dog
zinc finger MYND-type containing 8
Horse
zinc finger MYND-type containing 8
Publication Statistics
PubMed Score 30.26
PubMed score by year
PubTator Score 13.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title