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Tbio
ZMYND11
Zinc finger MYND domain-containing protein 11

Protein Summary
Description
Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA (PubMed:24675531). Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth. (Microbial infection) Inhibits Epstein-Barr virus EBNA2-mediated transcriptional activation and host cell proliferation, through direct interaction. The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381591
  • ENSP00000371003
  • ENSG00000015171
  • ENST00000381607
  • ENSP00000371020
  • ENST00000397959
  • ENSP00000381050
  • ENST00000397962
  • ENSP00000381053
  • ENST00000509513
  • ENSP00000424205
  • ENST00000558098
  • ENSP00000452959
  • ENST00000602682
  • ENSP00000473321

Symbol
  • BRAM1
  • BS69
  • BS69
  • BRAM1
  • MRD30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
microRNA
0.96
disease perturbation
0.93
viral protein
0.93
virus perturbation
0.92


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.82   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 231   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.82   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 231   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (63)
NCOR1
Tchem
Family:  TF
Novelty:  0.0021926
Score:  0.922
Data Source:  STRINGDB
H3F3A
Tbio
Novelty:  0.00508186
Score:  0.903
Data Source:  STRINGDB
EMSY
Tbio
Novelty:  0.02216272
Score:  0.884
Data Source:  STRINGDB
HIST3H3
Tbio
Novelty:  0.04915012
Score:  0.824
Data Source:  STRINGDB
DEAF1
Tbio
Family:  TF
Novelty:  0.01070035
Score:  0.8
Data Source:  STRINGDB
EFTUD2
Tbio
Novelty:  0.01805571
Score:  0.78
Data Source:  STRINGDB
H3F3C
Tbio
Novelty:  0.07135811
Score:  0.778
Data Source:  STRINGDB
HIST2H3A
Tbio
Novelty:  0.02749981
Score:  0.766
Data Source:  STRINGDB
ZHX1
Tbio
Family:  TF
Novelty:  0.04449432
Score:  0.758
Data Source:  STRINGDB
HIST1H3A
Tbio
Novelty:  0.00991842
Score:  0.746
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
1
1
14.5
brain measurement
1
1
0
5.6
1.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
14.5
brain measurement
0
5.6
1.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger MYND-type containing 11
VGNC:7873
735474
Macaque
zinc finger MYND-type containing 11
708761
Mouse
MGI:1913755
66505
Rat
RGD:1303252
291259
Dog
zinc finger MYND-type containing 11
VGNC:48651
478023
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger MYND-type containing 11
Macaque
zinc finger MYND-type containing 11
Mouse
Rat
Dog
zinc finger MYND-type containing 11
Publication Statistics
PubMed Score 58.82
PubMed score by year
PubTator Score 25.54
PubTator score by year
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Related Publications
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PMID
Year
Title