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Tbio
ZMYND10
Zinc finger MYND domain-containing protein 10

Protein Summary
Description
Plays a role in axonemal structure organization and motility (PubMed:23891469, PubMed:23891471). Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility (By similarity). May act by indirectly regulating transcription of dynein proteins (By similarity). This gene encodes a protein containing a MYND-type zinc finger domain that likely functions in assembly of the dynein motor. Mutations in this gene can cause primary ciliary dyskinesia. This gene is also considered a tumor suppressor gene and is often mutated, deleted, or hypermethylated and silenced in cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231749
  • ENSP00000231749
  • ENSG00000004838
  • ENST00000360165
  • ENSP00000353289

Symbol
  • BLU
  • BLU
  • FLU
  • CILD22
  • DNAAF7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.6
tissue sample
0.54
tissue
0.53
cell type or tissue
0.5
histone modification site profile
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.3   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 175   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.3   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 175   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
LRRC6
Tbio
Novelty:  0.10994386
Score:  0.911
Data Source:  STRINGDB
DNAAF5
Tbio
Novelty:  0.27921814
Score:  0.872
Data Source:  STRINGDB
DNAAF1
Tbio
Novelty:  0.03962936
Score:  0.846
Data Source:  STRINGDB
DNAAF4
Tbio
Novelty:  0.01730685
Score:  0.832
Data Source:  STRINGDB
DNAAF3
Tbio
Novelty:  0.06768631
Score:  0.827
Data Source:  STRINGDB
ARMC4
Tbio
Novelty:  0.17860406
Score:  0.82
Data Source:  STRINGDB
SPAG1
Tbio
Novelty:  0.01839474
Score:  0.816
Data Source:  STRINGDB
NPRL2
Tbio
Family:  Enzyme
Novelty:  0.02848752
Score:  0.811
Data Source:  STRINGDB
PRSS3
Tchem
Family:  Enzyme
Novelty:  0.00360444
Score:  0.809
Data Source:  STRINGDB
DNAAF2
Tbio
Novelty:  0.01254416
Score:  0.807
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
5
11
91.6
reticulocyte count
2
4
8
91
schizophrenia
4
2
0
1.1
83.3
chronotype measurement
1
1
0
1
76.5
mean reticulocyte volume
1
1
1
75.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
11
91.6
reticulocyte count
8
91
schizophrenia
0
1.1
83.3
chronotype measurement
0
1
76.5
mean reticulocyte volume
1
75.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger MYND-type containing 10
VGNC:8023
460392
Macaque
zinc finger MYND-type containing 10
702678
Mouse
MGI:2387863
114602
Rat
RGD:1303250
363139
Dog
zinc finger MYND-type containing 10
VGNC:48650
476615
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger MYND-type containing 10
Macaque
zinc finger MYND-type containing 10
Mouse
Rat
Dog
zinc finger MYND-type containing 10
Publication Statistics
PubMed Score 23.30
PubMed score by year
PubTator Score 166.44
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title