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Tbio
ZMPSTE24
CAAX prenyl protease 1 homolog

Protein Summary
Description
Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C. This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372759
  • ENSP00000361845
  • ENSG00000084073

Symbol
  • FACE1
  • STE24
  • HGPS
  • PRO1
  • FACE1
  • STE24
  • FACE-1
  • Ste24p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
histone modification site profile
0.87
interacting protein
0.84
disease perturbation
0.79
transcription factor binding site profile
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 367.5   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 387   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 367.5   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 387   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 53
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0