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Tbio
ZKSCAN1
Zinc finger protein with KRAB and SCAN domains 1

Protein Summary
Description
May be involved in transcriptional regulation. This gene encodes a member of the Kruppel C2H2-type zinc-finger family of proteins. This encoded protein may function as a transcription factor that regulates the expression of GABA type-A receptors in the brain. Transcripts from this gene have been shown to form stable and abundant circular RNAs. Elevated expression of this gene has been observed in gastric cancer and the encoded protein may stimulate migration and invasion of human gastric cancer cells. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324306
  • ENSP00000323148
  • ENSG00000106261

Symbol
  • KOX18
  • ZNF139
  • ZNF36
  • KOX18
  • ZNF36
  • PHZ-37
  • ZNF139
  • ZSCAN33
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
disease perturbation
0.9
microRNA
0.9
protein domain
0.85
transcription factor binding site profile
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.42   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.42   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (47)
STX12
Tbio
Novelty:  0.03836262
p_int:  0.999999165
p_ni:  8.35e-7
Score:  0.183
Data Source:  BioPlex,STRINGDB
PRKG1
Tchem
Family:  Kinase
Novelty:  0.0014943
p_int:  0.999998606
p_ni:  0.000001393
Score:  0.242
Data Source:  BioPlex,STRINGDB
STX7
Tbio
Novelty:  0.03109969
p_int:  0.999993234
p_ni:  0.000006765
p_wrong:  1e-9
Score:  0.224
Data Source:  BioPlex,STRINGDB
ZSCAN20
Tdark
Family:  TF
Novelty:  0.37441538
p_int:  0.999992564
p_ni:  0.000007431
p_wrong:  5e-9
Score:  0.532
Data Source:  BioPlex,STRINGDB
ZNF232
Tdark
Family:  TF
Novelty:  0.68288358
p_int:  0.999985292
p_ni:  0.000014708
Score:  0.638
Data Source:  BioPlex,STRINGDB
APBA3
Tbio
Novelty:  0.05059532
p_int:  0.999966893
p_ni:  0.000033106
p_wrong:  1e-9
Data Source:  BioPlex
ZSCAN32
Tdark
Family:  TF
Novelty:  3.83392226
p_int:  0.999964439
p_ni:  0.000035561
Score:  0.752
Data Source:  BioPlex,STRINGDB
ZNF397
Tbio
Family:  TF
Novelty:  0.60034816
p_int:  0.999954424
p_ni:  0.000045571
p_wrong:  5e-9
Score:  0.738
Data Source:  BioPlex,STRINGDB
ZKSCAN8
Tbio
Family:  TF
Novelty:  0.17881042
p_int:  0.999836875
p_ni:  0.000163124
p_wrong:  1e-9
Data Source:  BioPlex
PSME3
Tbio
Novelty:  0.01051254
p_int:  0.999280397
p_ni:  0.000719603
Score:  0.205
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Gene expression (Transcription) (R-HSA-74160)

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1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
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10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
1
1
78.3
FEV/FEC ratio
1
1
1
62.5
body height
1
1
1
62.1
1
1
0
1.3
61
erythrocyte count
1
1
1
52.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
78.3
FEV/FEC ratio
1
62.5
body height
1
62.1
0
1.3
61
erythrocyte count
1
52.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
zinc finger with KRAB and SCAN domains 1
710407
Mouse
MGI:1921820
74570
Rat
RGD:1560616
498160
Dog
zinc finger with KRAB and SCAN domains 1
VGNC:54094
489848
Horse
zinc finger with KRAB and SCAN domains 1
VGNC:49299
100067222
Species
Name
OMA
EggNOG
Inparanoid
Macaque
zinc finger with KRAB and SCAN domains 1
Mouse
Rat
Dog
zinc finger with KRAB and SCAN domains 1
Horse
zinc finger with KRAB and SCAN domains 1
Publication Statistics
PubMed Score 19.42
PubMed score by year
PubTator Score 7.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title