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Tbio
ZIC1
Zinc finger protein ZIC 1

Protein Summary
Description
Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity). This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. Th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282928
  • ENSP00000282928
  • ENSG00000152977

Symbol
  • ZIC
  • ZNF201
  • ZIC
  • CRS6
  • ZNF201
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.94
PubMedID
0.82
biological process
0.78
gene perturbation
0.68
small molecule perturbation
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 252.31   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 376   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 252.31   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 376   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (152)
SDR9C7
Tbio
Family:  Enzyme
Novelty:  0.01618496
p_int:  0.999983144
p_ni:  0.000016401
p_wrong:  4.56e-7
Data Source:  BioPlex
PLBD1
Tdark
Family:  Enzyme
Novelty:  0.27639575
p_int:  0.999940538
p_ni:  0.000059462
p_wrong:  1e-9
Data Source:  BioPlex
GDPD3
Tbio
Family:  Enzyme
Novelty:  0.18121762
p_int:  0.999887566
p_ni:  0.000112428
p_wrong:  6e-9
Data Source:  BioPlex
CTSH
Tchem
Family:  Enzyme
Novelty:  0.00336694
p_int:  0.999821636
p_ni:  0.000178364
Score:  0.156
Data Source:  BioPlex,STRINGDB
S100A7
Tbio
Novelty:  0.00434262
p_int:  0.99972651
p_ni:  0.00027349
Data Source:  BioPlex
SERPINB4
Tbio
Novelty:  0.00522283
p_int:  0.999455355
p_ni:  0.000544645
Data Source:  BioPlex
CAPNS2
Tbio
Novelty:  0.45658116
p_int:  0.999242426
p_ni:  0.000037596
p_wrong:  0.000719979
Data Source:  BioPlex
CPA4
Tchem
Family:  Enzyme
Novelty:  0.01439845
p_int:  0.999157201
p_ni:  0.000842799
Data Source:  BioPlex
PLA2G4E
Tbio
Family:  Enzyme
Novelty:  0.18739774
p_int:  0.99906458
p_ni:  0.000195099
p_wrong:  0.000740322
Score:  0.211
Data Source:  BioPlex,STRINGDB
RNASE7
Tbio
Family:  Enzyme
Novelty:  0.01866347
p_int:  0.998306494
p_ni:  0.001693343
p_wrong:  1.63e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (23)
Find Similar Targets
Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Neural Crest Differentiation
WikiPathways
Neural Crest Differentiation
WikiPathways
Neural Crest Differentiation
WikiPathways
Regulation of Actin Cytoskeleton
WikiPathways
ESC Pluripotency Pathways
Name
Explore in Pharos
Explore in Source
Neural Crest Differentiation
Neural Crest Differentiation
Neural Crest Differentiation
Regulation of Actin Cytoskeleton
ESC Pluripotency Pathways
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
2
6
0
18.9
98
brain volume measurement
22
2
22
89.9
brain connectivity measurement
4
3
4
88.2
functional brain measurement
1
1
0
9.4
86.6
language measurement
1
1
0
9.4
86.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
0
18.9
98
brain volume measurement
22
89.9
brain connectivity measurement
4
88.2
functional brain measurement
0
9.4
86.6
language measurement
0
9.4
86.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
Zic family member 1
715102
Mouse
MGI:106683
22771
Rat
RGD:620110
64618
Cow
Zic family member 1
VGNC:53627
516827
Pig
Zic family member 1
100153570
Species
Name
OMA
EggNOG
Inparanoid
Macaque
Zic family member 1
Mouse
Rat
Cow
Zic family member 1
Pig
Zic family member 1
Publication Statistics
PubMed Score 252.31
PubMed score by year
PubTator Score 73.31
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title