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Tbio
ZHX2
Zinc fingers and homeoboxes protein 2

Protein Summary
Description
Acts as a transcriptional repressor (PubMed:12741956). Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity). The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314393
  • ENSP00000314709
  • ENSG00000178764

Symbol
  • AFR1
  • KIAA0854
  • RAF
  • RAF
  • AFR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.93
histone modification site profile
0.82
kinase perturbation
0.76
transcription factor
0.75
disease
0.73


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.02   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 346   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.02   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 346   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
DOCK5
Tbio
Novelty:  0.03153692
p_int:  0.999999992
p_ni:  2e-9
p_wrong:  6e-9
Score:  0.212
Data Source:  BioPlex,STRINGDB
FAM206A
Tbio
Novelty:  0.01675868
p_int:  0.999999256
p_ni:  7.44e-7
Score:  0.379
Data Source:  BioPlex,STRINGDB
VRTN
Tdark
Novelty:  0.07572815
p_int:  0.999936327
p_ni:  0.000037968
p_wrong:  0.000025705
Data Source:  BioPlex
AFP
Tbio
Novelty:  0.00004755
Score:  0.811
Data Source:  STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.798
Data Source:  STRINGDB
NFYA
Tbio
Family:  TF
Novelty:  0.00507094
Score:  0.787
Data Source:  STRINGDB
BPGM
Tbio
Family:  Enzyme
Novelty:  0.03437401
Score:  0.757
Data Source:  STRINGDB
ZBTB20
Tbio
Family:  TF
Novelty:  0.01694308
Score:  0.751
Data Source:  STRINGDB
SLC25A37
Tbio
Family:  Transporter
Novelty:  0.01327453
Score:  0.719
Data Source:  STRINGDB
KRAS
Tclin
Family:  Enzyme
Novelty:  0.00013856
Score:  0.714
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
3
3
77.2
mean corpuscular volume
1
2
2
65.1
appendicular lean mass
1
1
1
48.8
reticulocyte count
1
1
1
32.3
neuroimaging measurement
1
1
1
20.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
3
77.2
mean corpuscular volume
2
65.1
appendicular lean mass
1
48.8
reticulocyte count
1
32.3
neuroimaging measurement
1
20.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc fingers and homeoboxes 2
VGNC:763
464363
Macaque
zinc fingers and homeoboxes 2
708694
Mouse
MGI:2683087
387609
Rat
RGD:727926
314988
Dog
zinc fingers and homeoboxes 2
VGNC:48632
482033
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc fingers and homeoboxes 2
Macaque
zinc fingers and homeoboxes 2
Mouse
Rat
Dog
zinc fingers and homeoboxes 2
Publication Statistics
PubMed Score 108.02
PubMed score by year
PubTator Score 1302.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title