You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ZFYVE9
Zinc finger FYVE domain-containing protein 9

Protein Summary
Description
Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. This gene encodes a double zinc finger motif-containing protein that participates in the transforming growth factor-beta (TGFB) signalling pathway. The encoded protein interacts directly with SMAD2 and SMAD3, and recruits SMAD2 to the TGFB receptor. There are multiple pseudogenes for this gene on chromosomes 2, 15, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287727
  • ENSP00000287727
  • ENSG00000157077
  • ENST00000357206
  • ENSP00000349737
  • ENST00000371591
  • ENSP00000360647

Symbol
  • MADHIP
  • SARA
  • SMADIP
  • NSP
  • SARA
  • MADHIP
  • SMADIP
  • PPP1R173
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
kinase perturbation
0.84
histone modification site profile
0.71
tissue sample
0.71
small molecule perturbation
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.69   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.69   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  0.999999998
p_ni:  2e-9
p_wrong:  1e-9
Score:  0.509
Data Source:  BioPlex,Reactome,STRINGDB
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
p_int:  0.999999995
p_ni:  5e-9
Score:  0.931
Data Source:  BioPlex,Reactome,STRINGDB
SMAD2
Tbio
Family:  TF
Novelty:  0.00040166
p_int:  0.999999952
p_ni:  4.5e-8
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
SMAD3
Tchem
Family:  TF
Novelty:  0.00048058
p_int:  0.99999986
p_ni:  9.1e-8
p_wrong:  4.8e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
NCKIPSD
Tbio
Novelty:  0.07453111
p_int:  0.999945448
p_ni:  0.000054544
p_wrong:  8e-9
Score:  0.173
Data Source:  BioPlex,STRINGDB
DEFA6
Tbio
Novelty:  0.0363171
p_int:  0.999703496
p_ni:  0.000294478
p_wrong:  0.000002026
Score:  0.188
Data Source:  BioPlex,STRINGDB
SMAD7
Tbio
Family:  TF
Novelty:  0.00116343
Score:  0.974
Data Source:  Reactome,STRINGDB
TGFBR1
Tchem
Family:  Kinase
Novelty:  0.00081645
Score:  0.964
Data Source:  Reactome,STRINGDB
SMURF2
Tchem
Family:  Enzyme
Novelty:  0.00920984
Score:  0.955
Data Source:  STRINGDB
PML
Tbio
Novelty:  0.00285474
Score:  0.95
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Downregulation of TGF-beta receptor signaling
Reactome
Loss of Function of SMAD2/3 in Cancer
Reactome
Loss of Function of TGFBR1 in Cancer
Name
Explore in Pharos
Explore in Source
Disease
Diseases of signal transduction
Downregulation of TGF-beta receptor signaling
Loss of Function of SMAD2/3 in Cancer
Loss of Function of TGFBR1 in Cancer
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
17.8
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger FYVE-type containing 9
VGNC:10873
456855
Macaque
zinc finger FYVE-type containing 9
713155
Mouse
MGI:2652838
230597
Rat
RGD:1310856
313477
Dog
zinc finger FYVE-type containing 9
VGNC:48628
475352
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger FYVE-type containing 9
Macaque
zinc finger FYVE-type containing 9
Mouse
Rat
Dog
zinc finger FYVE-type containing 9
Publication Statistics
PubMed Score 155.69
PubMed score by year
PubTator Score 331.40
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title