Protein Summary
Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport (PubMed:17082457). Promotes axonal elongation and contributes to the establishment of neuronal cell polarity (By similarity). Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner (PubMed:19289470). Contributes to both the formation and stabilization of the tubular ER network (PubMed:24668814). Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections (PubMed:23969831). Acts as an adapter protein and facilitates the interaction of KIF5A with VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 and the ZFYVE27-KIF5A complex contributes to the transport of these proteins in neurons. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a KIF5A/B-dependent manner (PubMed:21976701). This gene encodes a protein with several transmembrane domains, a Rab11-binding do ...more
- ENST00000337540
- ENSP00000337993
- ENSG00000155256
- ENST00000357540
- ENSP00000350148
- ENST00000359980
- ENSP00000353069
- ENST00000370610
- ENSP00000359642
- ENST00000370613
- ENSP00000359646
- ENST00000393677
- ENSP00000377282
- ENST00000423811
- ENSP00000409594
- SPG33
- SPG33
- PROTRUDIN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor | 0.8 | ||
histone modification site profile | 0.78 | ||
cell type or tissue | 0.76 | ||
cellular component | 0.75 | ||
transcription factor binding site profile | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.58 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 155 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.58 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 155 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (83)
ENTR1
Novelty: 0.32267064
p_int: 0.999999859
p_ni: 1.3e-7
p_wrong: 1.1e-8
Score: 0.187
Data Source: BioPlex,STRINGDB
TNFSF18
Novelty: 0.01423949
p_int: 0.999806811
p_ni: 0.000009083
p_wrong: 0.000184106
Data Source: BioPlex
ZFAND2B
Novelty: 0.28286118
p_int: 0.99878178
p_ni: 0.00027096
p_wrong: 0.000947259
Data Source: BioPlex
ATP5F1B
Family: Enzyme
Novelty: 0.01053177
p_int: 0.998426342
p_ni: 0.001573658
Score: 0.537
Data Source: BioPlex,STRINGDB
MT-ATP8
Family: Enzyme
Novelty: 0.00249065
p_int: 0.998401508
p_ni: 0.001598453
p_wrong: 3.9e-8
Score: 0.665
Data Source: BioPlex,STRINGDB
ATP5PB
Family: Enzyme
Novelty: 0.07345384
p_int: 0.998331679
p_ni: 0.001668321
Score: 0.552
Data Source: BioPlex,STRINGDB
VAPA
Novelty: 0.00169209
p_int: 0.994829944
p_ni: 0.005170056
Score: 0.776
Data Source: BioPlex,STRINGDB
MOSPD2
Novelty: 0.14602473
p_int: 0.991166397
p_ni: 0.008833499
p_wrong: 1.05e-7
Score: 0.159
Data Source: BioPlex,STRINGDB
ATP5F1A
Family: Enzyme
Novelty: 0.01052213
p_int: 0.976628661
p_ni: 0.023371339
Score: 0.686
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (1)
KEGG (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
KEGG | Endocytosis | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Endocytosis | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (2)
Components (10)
Processes (6)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
alpha-linolenic acid measurement | 1 | 1 | 1 | 0.1 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
alpha-linolenic acid measurement | 1 | 0.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | zinc finger FYVE-type containing 27 | 707273 | ||||||
Mouse | MGI:1919602 | 319740 | ||||||
Rat | RGD:735177 | 309376 | ||||||
Dog | zinc finger FYVE-type containing 27 | VGNC:48627 | 486825 | |||||
Horse | zinc finger FYVE-type containing 27 | VGNC:25231 | 100060913 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | zinc finger FYVE-type containing 27 | |||||
Mouse | ||||||
Rat | ||||||
Dog | zinc finger FYVE-type containing 27 | |||||
Horse | zinc finger FYVE-type containing 27 | |||||
Publication Statistics
PubMed Score 22.58
PubMed score by year
PubTator Score 9.25
PubTator score by year
Related Publications
Text Mined References (17)
GeneRif Annotations (8)
Items per page:
0 of 0
PMID | Year | Title |
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