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Tbio
ZFYVE27
Protrudin

Protein Summary
Description
Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport (PubMed:17082457). Promotes axonal elongation and contributes to the establishment of neuronal cell polarity (By similarity). Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner (PubMed:19289470). Contributes to both the formation and stabilization of the tubular ER network (PubMed:24668814). Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections (PubMed:23969831). Acts as an adapter protein and facilitates the interaction of KIF5A with VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 and the ZFYVE27-KIF5A complex contributes to the transport of these proteins in neurons. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a KIF5A/B-dependent manner (PubMed:21976701). This gene encodes a protein with several transmembrane domains, a Rab11-binding do ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337540
  • ENSP00000337993
  • ENSG00000155256
  • ENST00000357540
  • ENSP00000350148
  • ENST00000359980
  • ENSP00000353069
  • ENST00000370610
  • ENSP00000359642
  • ENST00000370613
  • ENSP00000359646
  • ENST00000393677
  • ENSP00000377282
  • ENST00000423811
  • ENSP00000409594

Symbol
  • SPG33
  • SPG33
  • PROTRUDIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.8
histone modification site profile
0.78
cell type or tissue
0.76
cellular component
0.75
transcription factor binding site profile
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.58   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.58   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
ENTR1
Tbio
Novelty:  0.32267064
p_int:  0.999999859
p_ni:  1.3e-7
p_wrong:  1.1e-8
Score:  0.187
Data Source:  BioPlex,STRINGDB
TNFSF18
Tbio
Novelty:  0.01423949
p_int:  0.999806811
p_ni:  0.000009083
p_wrong:  0.000184106
Data Source:  BioPlex
ZFAND2B
Tbio
Novelty:  0.28286118
p_int:  0.99878178
p_ni:  0.00027096
p_wrong:  0.000947259
Data Source:  BioPlex
ATP5F1B
Tbio
Family:  Enzyme
Novelty:  0.01053177
p_int:  0.998426342
p_ni:  0.001573658
Score:  0.537
Data Source:  BioPlex,STRINGDB
MT-ATP8
Tbio
Family:  Enzyme
Novelty:  0.00249065
p_int:  0.998401508
p_ni:  0.001598453
p_wrong:  3.9e-8
Score:  0.665
Data Source:  BioPlex,STRINGDB
ATP5PB
Tbio
Family:  Enzyme
Novelty:  0.07345384
p_int:  0.998331679
p_ni:  0.001668321
Score:  0.552
Data Source:  BioPlex,STRINGDB
PLXDC2
Tbio
Novelty:  0.06496695
p_int:  0.996551019
p_ni:  0.003448981
Data Source:  BioPlex
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.994829944
p_ni:  0.005170056
Score:  0.776
Data Source:  BioPlex,STRINGDB
MOSPD2
Tbio
Novelty:  0.14602473
p_int:  0.991166397
p_ni:  0.008833499
p_wrong:  1.05e-7
Score:  0.159
Data Source:  BioPlex,STRINGDB
ATP5F1A
Tbio
Family:  Enzyme
Novelty:  0.01052213
p_int:  0.976628661
p_ni:  0.023371339
Score:  0.686
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alpha-linolenic acid measurement
1
1
1
0.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alpha-linolenic acid measurement
1
0.1
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
zinc finger FYVE-type containing 27
707273
Mouse
MGI:1919602
319740
Rat
RGD:735177
309376
Dog
zinc finger FYVE-type containing 27
VGNC:48627
486825
Horse
zinc finger FYVE-type containing 27
VGNC:25231
100060913
Species
Name
OMA
EggNOG
Inparanoid
Macaque
zinc finger FYVE-type containing 27
Mouse
Rat
Dog
zinc finger FYVE-type containing 27
Horse
zinc finger FYVE-type containing 27
Publication Statistics
PubMed Score 22.58
PubMed score by year
PubTator Score 9.25
PubTator score by year
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Related Publications
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PMID
Year
Title