Tbio ZFYVE27 Protrudin

Protein Summary

Description

Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport (PubMed:17082457). Promotes axonal elongation and contributes to the establishment of neuronal cell polarity (By similarity). Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner (PubMed:19289470). Contributes to both the formation and stabilization of the tubular ER network (PubMed:24668814). Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections (PubMed:23969831). Acts as an adapter protein and facilitates the interaction of KIF5A with VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 and the ZFYVE27-KIF5A complex contributes to the transport of these proteins in neurons. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a KIF5A/B-dependent manner (PubMed:21976701). This gene encodes a protein with several transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote neurite formation. A mutation in this gene has been reported to be associated with hereditary spastic paraplegia, however the pathogenicity of the mutation, which may simply represent a polymorphism, is unclear. [provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• Q5T4F4
• B7Z3S0
• B7Z404
• B7Z626
• G8JLC3
• G8JLF0
• J3KP98
• Q5T4F1
• Q5T4F2
• Q5T4F3
• Q8N1K0
• Q8N6D6
• Q8NCA0
• Q8NDE4
• Q96M08

Gene Name

• ZFYVE27

Ensembl ID

• ENST00000337540
• ENSP00000337993
• ENSG00000155256
• ENST00000357540
• ENSP00000350148
• ENST00000359980
• ENSP00000353069
• ENST00000370610
• ENSP00000359642
• ENST00000370613
• ENSP00000359646
• ENST00000393677
• ENSP00000377282
• ENST00000423811
• ENSP00000409594

Symbol

• SPG33
• SPG33
• PROTRUDIN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.8
histone modification site profile	0.78
cell type or tissue	0.76
cellular component	0.75
transcription factor binding site profile	0.75

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.58   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 155   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.58   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (83)

Explore Interacting Targets

1 – 10 of 83

• See Interactions on String-DB

ENTR1

Tbio

Novelty:  0.32267064

p_int:  0.999999859

p_ni:  1.3e-7

p_wrong:  1.1e-8

Score:  0.187

Data Source:  BioPlex,STRINGDB

TNFSF18

Tbio

Novelty:  0.01423949

p_int:  0.999806811

p_ni:  0.000009083

p_wrong:  0.000184106

Data Source:  BioPlex

ZFAND2B

Tbio

Novelty:  0.28286118

p_int:  0.99878178

p_ni:  0.00027096

p_wrong:  0.000947259

Data Source:  BioPlex

ATP5F1B

Tbio

Family:  Enzyme

Novelty:  0.01053177

p_int:  0.998426342

p_ni:  0.001573658

Score:  0.537

Data Source:  BioPlex,STRINGDB

MT-ATP8

Tbio

Family:  Enzyme

Novelty:  0.00249065

p_int:  0.998401508

p_ni:  0.001598453

p_wrong:  3.9e-8

Score:  0.665

Data Source:  BioPlex,STRINGDB

ATP5PB

Tbio

Family:  Enzyme

Novelty:  0.07345384

p_int:  0.998331679

p_ni:  0.001668321

Score:  0.552

Data Source:  BioPlex,STRINGDB

PLXDC2

Tbio

Novelty:  0.06496695

p_int:  0.996551019

p_ni:  0.003448981

Data Source:  BioPlex

VAPA

Tbio

Novelty:  0.00169209

p_int:  0.994829944

p_ni:  0.005170056

Score:  0.776

Data Source:  BioPlex,STRINGDB

MOSPD2

Tbio

Novelty:  0.14602473

p_int:  0.991166397

p_ni:  0.008833499

p_wrong:  1.05e-7

Score:  0.159

Data Source:  BioPlex,STRINGDB

ATP5F1A

Tbio

Family:  Enzyme

Novelty:  0.01052213

p_int:  0.976628661

p_ni:  0.023371339

Score:  0.686

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

KEGG (1)

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5

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Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Endocytosis	309 targets	path:hsa04144

Name	Explore in Pharos	Explore in Source
Endocytosis	309 targets	path:hsa04144

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (18)

Functions (2)

Components (10)

Processes (6)

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1 – 2 of 2

GO Term	Evidence	Assigned by
protein self-association	Inferred from Direct Assay (IDA)	UniProtKB
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (1)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
alpha-linolenic acid measurement	EFO_0007759	1	1	1		0.1

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
alpha-linolenic acid measurement	EFO_0007759	1		0.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Cell membrane
Cell projection
Complete proteome
Disease mutation
Endoplasmic reticulum
Endosome
Hereditary spastic paraplegia
Membrane

GWAS Trait Find Similar Targets

No Header	No Header
alpha-linolenic acid measurement

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	zinc finger FYVE-type containing 27		707273
Mouse	zinc finger, FYVE domain containing 27	MGI:1919602	319740
Rat	zinc finger FYVE-type containing 27	RGD:735177	309376
Dog	zinc finger FYVE-type containing 27	VGNC:48627	486825
Horse	zinc finger FYVE-type containing 27	VGNC:25231	100060913

Species	Name	OMA	EggNOG	Inparanoid
Macaque	zinc finger FYVE-type containing 27
Mouse	zinc finger, FYVE domain containing 27
Rat	zinc finger FYVE-type containing 27
Dog	zinc finger FYVE-type containing 27
Horse	zinc finger FYVE-type containing 27

Publication Statistics

PubMed Score 22.58

PubMed score by year

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PubTator Score 9.25

PubTator score by year

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Related Publications

Text Mined References (17)

GeneRif Annotations (8)

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10

0 of 0

PMID	Year	Title