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Tbio
ZFYVE27
Protrudin

Protein Summary
Description
Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport (PubMed:17082457). Promotes axonal elongation and contributes to the establishment of neuronal cell polarity (By similarity). Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner (PubMed:19289470). Contributes to both the formation and stabilization of the tubular ER network (PubMed:24668814). Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections (PubMed:23969831). Acts as an adapter protein and facilitates the interaction of KIF5A with VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 and the ZFYVE27-KIF5A complex contributes to the transport of these proteins in neurons. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a KIF5A/B-dependent manner (PubMed:21976701). This gene encodes a protein with several transmembrane domains, a Rab11-binding do ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337540
  • ENSP00000337993
  • ENSG00000155256
  • ENST00000357540
  • ENSP00000350148
  • ENST00000359980
  • ENSP00000353069
  • ENST00000370610
  • ENSP00000359642
  • ENST00000370613
  • ENSP00000359646
  • ENST00000393677
  • ENSP00000377282
  • ENST00000423811
  • ENSP00000409594

Symbol
  • SPG33
  • SPG33
  • PROTRUDIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.8
histone modification site profile
0.78
cell type or tissue
0.76
cellular component
0.75
transcription factor binding site profile
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.48   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.48   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0