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Tbio
ZFYVE26
Zinc finger FYVE domain-containing protein 26

Protein Summary
Description
Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair. This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. [provided by RefSeq, Oct 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
disease perturbation
0.9
microRNA
0.8
protein domain
0.73
cellular component
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.43   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.43   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (73)
OPRM1
Tclin
Family:  GPCR
Novelty:  0.0003701
p_int:  0.999799451
p_ni:  0.000007509
p_wrong:  0.00019304
Score:  0.239
Data Source:  BioPlex,STRINGDB
FIS1
Tbio
Novelty:  0.0033607
p_int:  0.907767514
p_ni:  0.010815215
p_wrong:  0.08141727
Data Source:  BioPlex
SPG11
Tbio
Novelty:  0.00697875
Score:  0.954
Data Source:  STRINGDB
AP5Z1
Tbio
Family:  TF
Novelty:  0.14368974
Score:  0.945
Data Source:  STRINGDB
AP5B1
Tdark
Novelty:  0.06116142
Score:  0.901
Data Source:  STRINGDB
AP5S1
Tdark
Novelty:  1.92515745
Score:  0.895
Data Source:  STRINGDB
TTC19
Tbio
Novelty:  0.08251578
Score:  0.86
Data Source:  STRINGDB
KIF13A
Tbio
Novelty:  0.04988003
Score:  0.707
Data Source:  STRINGDB
SOGA1
Tbio
Novelty:  0.08349978
Score:  0.699
Data Source:  STRINGDB
PLEK2
Tbio
Novelty:  0.11141066
Score:  0.692
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
73.4
platelet crit
1
1
1
71.7
erythrocyte count
1
1
1
66.2
mean corpuscular volume
1
1
1
54.5
glomerular filtration rate
1
1
1
25.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
73.4
platelet crit
1
71.7
erythrocyte count
1
66.2
mean corpuscular volume
1
54.5
glomerular filtration rate
1
25.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger FYVE-type containing 26
VGNC:12445
452989
Macaque
zinc finger FYVE-type containing 26
711274
Mouse
MGI:1924767
211978
Rat
RGD:1307820
314265
Dog
zinc finger FYVE-type containing 26
VGNC:48626
490745
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger FYVE-type containing 26
Macaque
zinc finger FYVE-type containing 26
Mouse
Rat
Dog
zinc finger FYVE-type containing 26
Publication Statistics
PubMed Score 25.43
PubMed score by year
PubTator Score 22.19
PubTator score by year
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Related Publications
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PMID
Year
Title