You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ZFYVE1
Zinc finger FYVE domain-containing protein 1

Protein Summary
Description
The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318876
  • ENSP00000326921
  • ENSG00000165861
  • ENST00000394207
  • ENSP00000377757
  • ENST00000555072
  • ENSP00000452232
  • ENST00000556143
  • ENSP00000450742

Symbol
  • DFCP1
  • KIAA1589
  • TAFF1
  • ZNFN2A1
  • SR3
  • DFCP1
  • TAFF1
  • ZNFN2A1
  • PPP1R172
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.86
transcription factor
0.8
cell type or tissue
0.74
protein domain
0.73
cellular component
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 271.66   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 271.66   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (90)
MID1
Tbio
Family:  Enzyme
Novelty:  0.02400169
p_int:  0.999854238
p_ni:  0.000145629
p_wrong:  1.33e-7
Score:  0.215
Data Source:  BioPlex,STRINGDB
KCTD6
Tbio
Novelty:  0.43478298
p_int:  0.998996994
p_ni:  0.000797059
p_wrong:  0.000205947
Score:  0.332
Data Source:  BioPlex,STRINGDB
LIMD1
Tbio
Novelty:  0.04868333
p_int:  0.992133159
p_ni:  0.007863586
p_wrong:  0.000003255
Score:  0.209
Data Source:  BioPlex,STRINGDB
LONRF2
Tdark
Family:  Enzyme
Novelty:  1.01811251
p_int:  0.886325613
p_ni:  0.002660945
p_wrong:  0.111013442
Score:  0.218
Data Source:  BioPlex,STRINGDB
WIPI2
Tbio
Novelty:  0.02685992
Score:  0.825
Data Source:  STRINGDB
STAM2
Tbio
Novelty:  0.04440236
Score:  0.822
Data Source:  STRINGDB
STAM
Tbio
Novelty:  0.0332731
Score:  0.822
Data Source:  STRINGDB
PIK3C3
Tchem
Family:  Kinase
Novelty:  0.00269825
Score:  0.784
Data Source:  STRINGDB
ATG14
Tbio
Novelty:  0.00914791
Score:  0.78
Data Source:  STRINGDB
WIPI1
Tbio
Novelty:  0.01070744
Score:  0.756
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
81.3
red blood cell density measurement
1
1
1
75.7
C-reactive protein measurement
1
1
1
72.3
eosinophil percentage of leukocytes
1
1
1
63.7
eosinophil count
2
1
2
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
81.3
red blood cell density measurement
1
75.7
C-reactive protein measurement
1
72.3
eosinophil percentage of leukocytes
1
63.7
eosinophil count
2
58.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger FYVE-type containing 1
VGNC:12451
467502
Macaque
zinc finger FYVE-type containing 1
696313
Mouse
MGI:3026685
217695
Rat
RGD:1307795
299188
Dog
zinc finger FYVE-type containing 1
VGNC:48622
490768
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger FYVE-type containing 1
Macaque
zinc finger FYVE-type containing 1
Mouse
Rat
Dog
zinc finger FYVE-type containing 1
Publication Statistics
PubMed Score 271.66
PubMed score by year
PubTator Score 46.72
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title