Tbio ZFYVE1 Zinc finger FYVE domain-containing protein 1

Protein Summary

Description

The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Uniprot Accession IDs

• Q9HBF4
• J3KNL9
• Q8WYX7
• Q96K57
• Q9BXP9
• Q9HCI3

Gene Name

• ZFYVE1

Ensembl ID

• ENST00000318876
• ENSP00000326921
• ENSG00000165861
• ENST00000394207
• ENSP00000377757
• ENST00000555072
• ENSP00000452232
• ENST00000556143
• ENSP00000450742

Symbol

• DFCP1
• KIAA1589
• TAFF1
• ZNFN2A1
• SR3
• DFCP1
• TAFF1
• ZNFN2A1
• PPP1R172

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
phenotype	0.86
transcription factor	0.8
cell type or tissue	0.74
protein domain	0.73
cellular component	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 271.66   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 152   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 271.66   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (90)

Explore Interacting Targets

1 – 10 of 90

• See Interactions on String-DB

MID1

Tbio

Family:  Enzyme

Novelty:  0.02400169

p_int:  0.999854238

p_ni:  0.000145629

p_wrong:  1.33e-7

Score:  0.215

Data Source:  BioPlex,STRINGDB

KCTD6

Tbio

Novelty:  0.43478298

p_int:  0.998996994

p_ni:  0.000797059

p_wrong:  0.000205947

Score:  0.332

Data Source:  BioPlex,STRINGDB

LIMD1

Tbio

Novelty:  0.04868333

p_int:  0.992133159

p_ni:  0.007863586

p_wrong:  0.000003255

Score:  0.209

Data Source:  BioPlex,STRINGDB

LONRF2

Tdark

Family:  Enzyme

Novelty:  1.01811251

p_int:  0.886325613

p_ni:  0.002660945

p_wrong:  0.111013442

Score:  0.218

Data Source:  BioPlex,STRINGDB

WIPI2

Tbio

Novelty:  0.02685992

Score:  0.825

Data Source:  STRINGDB

STAM2

Tbio

Novelty:  0.04440236

Score:  0.822

Data Source:  STRINGDB

STAM

Tbio

Novelty:  0.0332731

Score:  0.822

Data Source:  STRINGDB

PIK3C3

Tchem

Family:  Kinase

Novelty:  0.00269825

Score:  0.784

Data Source:  STRINGDB

ATG14

Tbio

Novelty:  0.00914791

Score:  0.78

Data Source:  STRINGDB

WIPI1

Tbio

Novelty:  0.01070744

Score:  0.756

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

KEGG (1)

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5

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Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Autophagy - animal	137 targets	path:hsa04140

Name	Explore in Pharos	Explore in Source
Autophagy - animal	137 targets	path:hsa04140

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Functions (4)

Components (8)

Processes (3)

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1 – 4 of 4

GO Term	Evidence	Assigned by
1-phosphatidylinositol binding	Inferred from Direct Assay (IDA)	UniProtKB
phosphatidylinositol-3,4,5-trisphosphate binding	Inferred from Direct Assay (IDA)	UniProtKB
phosphatidylinositol-3,4-bisphosphate binding	Inferred from Direct Assay (IDA)	UniProtKB
zinc ion binding	Non-traceable Author Statement (NAS)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (13)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 13

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	2	2	2		81.3
red blood cell density measurement	EFO_0007978	1	1	1		75.7
C-reactive protein measurement	EFO_0004458	1	1	1		72.3
eosinophil percentage of leukocytes	EFO_0007991	1	1	1		63.7
eosinophil count	EFO_0004842	2	1	2		58.4

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 13

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	2		81.3
red blood cell density measurement	EFO_0007978	1		75.7
C-reactive protein measurement	EFO_0004458	1		72.3
eosinophil percentage of leukocytes	EFO_0007991	1		63.7
eosinophil count	EFO_0004842	2		58.4

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Endoplasmic reticulum
Golgi apparatus
Metal-binding
Reference proteome
Repeat
Zinc
Zinc-finger

GWAS Trait Find Similar Targets

No Header	No Header
C-reactive protein measurement
cognitive function measurement
eosinophil count
eosinophil percentage of leukocytes
intelligence
low density lipoprotein cholesterol measurement
mean corpuscular volume
red blood cell density measurement
red blood cell distribution width
reticulocyte count

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	zinc finger FYVE-type containing 1	VGNC:12451	467502
Macaque	zinc finger FYVE-type containing 1		696313
Mouse	zinc finger, FYVE domain containing 1	MGI:3026685	217695
Rat	zinc finger FYVE-type containing 1	RGD:1307795	299188
Dog	zinc finger FYVE-type containing 1	VGNC:48622	490768

Species	Name	OMA	EggNOG	Inparanoid
Chimp	zinc finger FYVE-type containing 1
Macaque	zinc finger FYVE-type containing 1
Mouse	zinc finger, FYVE domain containing 1
Rat	zinc finger FYVE-type containing 1
Dog	zinc finger FYVE-type containing 1

Publication Statistics

PubMed Score 271.66

PubMed score by year

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PubTator Score 46.72

PubTator score by year

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Related Publications

Text Mined References (19)

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10

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PMID	Year	Title