ZFPM2
Zinc finger protein ZFPM2
Protein Summary
Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By similarity). The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promote ...more
- ENST00000407775
- ENSP00000384179
- ENSG00000169946
- FOG2
- ZNF89B
- DIH3
- FOG2
- SRXY9
- ZNF89B
- hFOG-2
- ZC2HC11B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 0.99 | ||
molecular function | 0.91 | ||
biological process | 0.88 | ||
PubMedID | 0.84 | ||
phenotype | 0.77 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 104.37 (req: < 5)
Gene RIFs: 25 (req: <= 3)
Antibodies: 129 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 104.37 (req: >= 5)
Gene RIFs: 25 (req: > 3)
Antibodies: 129 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 26
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (55)
Nearest Tclin Targets
Pathways (3)
Reactome (2)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Factors involved in megakaryocyte development and platelet production | ||||
Reactome | Hemostasis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Factors involved in megakaryocyte development and platelet production | ||||
Hemostasis | ||||
Viral Interactions (0)
Gene Ontology Terms (29)
Functions (8)
Components (3)
Processes (18)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Non-traceable Author Statement (NAS) | BHF-UCL | |||
Non-traceable Author Statement (NAS) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (30)
Items per page:
1 – 5 of 30
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
testosterone measurement | 4 | 3 | 4 | 93 | |||||
neutrophil count | 2 | 2 | 2 | 87.2 | |||||
4 | 3 | 1 | 1.1 | 87.1 | |||||
electrocardiography | 1 | 2 | 96 | 86.6 | |||||
2 | 3 | 3 | 84 | ||||||
Items per page:
1 – 5 of 30
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
testosterone measurement | 4 | 93 | |||||
neutrophil count | 2 | 87.2 | |||||
1 | 1.1 | 87.1 | |||||
electrocardiography | 96 | 86.6 | |||||
3 | 84 | ||||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | zinc finger protein, FOG family member 2 | VGNC:10226 | 464332 | |||||
Mouse | MGI:1334444 | 22762 | ||||||
Rat | ||||||||
Dog | zinc finger protein, FOG family member 2 | VGNC:48619 | 481997 | |||||
Horse | zinc finger protein, FOG family member 2 | VGNC:25224 | 100063119 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | zinc finger protein, FOG family member 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | zinc finger protein, FOG family member 2 | |||||
Horse | zinc finger protein, FOG family member 2 | |||||
Publication Statistics
PubMed Score 104.37
PubMed score by year
PubTator Score 43.62
PubTator score by year
Related Publications
Text Mined References (47)
GeneRif Annotations (25)
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0 of 0
PMID | Year | Title |
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