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Tbio
ZFPL1
Zinc finger protein-like 1

Protein Summary
Description
Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294258
  • ENSP00000294258
  • ENSG00000162300

Symbol
  • MCG4
  • D11S750
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
histone modification site profile
0.89
interacting protein
0.85
co-expressed gene
0.65
transcription factor binding site profile
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.82   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.82   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.999999789
p_ni:  2.11e-7
Score:  0.196
Data Source:  BioPlex,STRINGDB
PBXIP1
Tbio
Novelty:  0.15404864
p_int:  0.999985559
p_ni:  0.000014441
Data Source:  BioPlex
OSBPL3
Tbio
Novelty:  0.06106368
p_int:  0.999969045
p_ni:  0.000030955
Score:  0.165
Data Source:  BioPlex,STRINGDB
ACBD5
Tbio
Novelty:  0.10433432
p_int:  0.999825521
p_ni:  0.000173764
p_wrong:  7.15e-7
Score:  0.547
Data Source:  BioPlex,STRINGDB
OSBPL2
Tbio
Novelty:  0.03946704
p_int:  0.999737052
p_ni:  0.000262947
Score:  0.547
Data Source:  BioPlex,STRINGDB
SYNE4
Tbio
Novelty:  0.0739848
p_int:  0.999638545
p_ni:  0.000339947
p_wrong:  0.000021508
Data Source:  BioPlex
ERGIC2
Tbio
Novelty:  0.08610944
p_int:  0.999439315
p_ni:  0.000560685
Score:  0.165
Data Source:  BioPlex,STRINGDB
OSBPL6
Tbio
Novelty:  0.25692861
p_int:  0.999376642
p_ni:  0.000623358
Score:  0.165
Data Source:  BioPlex,STRINGDB
TRDN
Tbio
Novelty:  0.00501554
p_int:  0.999135342
p_ni:  0.000861565
p_wrong:  0.000003093
Data Source:  BioPlex
SLC39A4
Tbio
Family:  Transporter
Novelty:  0.00742159
p_int:  0.998560239
p_ni:  0.001439691
p_wrong:  6.9e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
2
2
87.4
high density lipoprotein cholesterol measurement
1
1
1
48.5
1
1
0
1.9
13.9
platelet crit
1
1
1
13.1
metabolic syndrome
1
1
1
8.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
87.4
high density lipoprotein cholesterol measurement
1
48.5
0
1.9
13.9
platelet crit
1
13.1
metabolic syndrome
1
8.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein like 1
VGNC:7652
451311
Macaque
zinc finger protein like 1
716932
Mouse
MGI:1891017
81909
Rat
RGD:1586738
684755
Dog
zinc finger protein like 1
VGNC:48618
483750
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein like 1
Macaque
zinc finger protein like 1
Mouse
Rat
Dog
zinc finger protein like 1
Publication Statistics
PubMed Score 12.82
PubMed score by year
PubTator Score 6.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title