You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ZFP57
Zinc finger protein 57 homolog

Protein Summary
Description
Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element (By similarity). Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. The protein encoded by this gene is a zinc finger protein containing a KRAB domain. Studies in mouse suggest that this protein may function as a transcriptional repressor. Mutations in this gene have been associated with transient neonatal diabetes mellitus type 1 (TNDM1).[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376881
  • ENSP00000366078
  • ENSG00000204644
  • ENST00000376883
  • ENSP00000366080
  • ENST00000383628
  • ENSP00000373124
  • ENSG00000206510
  • ENST00000416974
  • ENSP00000396462
  • ENSG00000223858
  • ENST00000435906
  • ENSP00000412932
  • ENSG00000226858
  • ENST00000437216
  • ENSP00000398086
  • ENSG00000223852
  • ENST00000446005
  • ENSP00000394222
  • ENSG00000234669
  • ENST00000448114
  • ENSP00000409118
  • ENSG00000232099
  • ENST00000488757
  • ENSP00000418259
  • ENST00000547542
  • ENSP00000447492
  • ENST00000547911
  • ENSP00000449556
  • ENST00000548001
  • ENSP00000446541
  • ENST00000548337
  • ENSP00000449407
  • ENST00000548574
  • ENSP00000446798
  • ENST00000548769
  • ENSP00000448351
  • ENST00000549167
  • ENSP00000449230
  • ENST00000549501
  • ENSP00000447698
  • ENST00000552809
  • ENSP00000450279
  • ENST00000552898
  • ENSP00000450397
  • ENST00000552987
  • ENSP00000448634
  • ENST00000553137
  • ENSP00000447495

Symbol
  • C6orf40
  • ZNF698
  • TNDM1
  • ZNF698
  • C6orf40
  • bA145L22
  • bA145L22.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.62
PubMedID
0.6
tissue
0.6
protein domain
0.58
transcription factor
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.5   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.5   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0