Tbio ZFC3H1 Zinc finger C3H1 domain-containing protein

Protein Summary

Description

Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters.

Uniprot Accession IDs

• O60293
• Q6GMU1
• Q6P2S9
• Q6ZV36
• Q96BE7

Gene Name

• ZFC3H1

Ensembl ID

• ENST00000378743
• ENSP00000368017
• ENSG00000133858
• ENST00000548100
• ENSP00000450044
• ENST00000552994
• ENSP00000446995

Symbol

• CCDC131
• KIAA0546
• PSRC2
• CSRC2
• PSRC2
• CCDC131

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	1
transcription factor binding site profile	0.92
histone modification site profile	0.85
virus perturbation	0.76
cell type or tissue	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.43   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 54   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.43   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (147)

Explore Interacting Targets

1 – 10 of 147

• See Interactions on String-DB

MPHOSPH6

Tbio

Family:  Enzyme

Novelty:  0.24387167

p_int:  0.999999922

p_ni:  7.7e-8

Score:  0.931

Data Source:  BioPlex,STRINGDB

BUB3

Tbio

Novelty:  0.00714143

p_int:  0.999999854

p_ni:  1.46e-7

Score:  0.28

Data Source:  BioPlex,STRINGDB

SMYD2

Tchem

Family:  Epigenetic

Novelty:  0.0192516

p_int:  0.999999501

p_ni:  4.99e-7

Score:  0.227

Data Source:  BioPlex,STRINGDB

CARNMT1

Tbio

Family:  Enzyme

Novelty:  0.28121779

p_int:  0.999999105

p_ni:  8.95e-7

Data Source:  BioPlex

TBC1D1

Tbio

Novelty:  0.0122464

p_int:  0.999998777

p_ni:  5e-9

p_wrong:  0.000001218

Score:  0.251

Data Source:  BioPlex,STRINGDB

EXOSC7

Tbio

Family:  Enzyme

Novelty:  0.07422851

p_int:  0.999975959

p_ni:  0.000024041

Score:  0.951

Data Source:  BioPlex,STRINGDB

SLBP

Tbio

Novelty:  0.00685735

p_int:  0.999973154

p_ni:  0.000013797

p_wrong:  0.000013048

Score:  0.244

Data Source:  BioPlex,STRINGDB

SUFU

Tbio

Novelty:  0.00475249

p_int:  0.999966145

p_ni:  0.000033855

Data Source:  BioPlex

PAPOLG

Tbio

Family:  Enzyme

Novelty:  0.02468251

p_int:  0.999957634

p_ni:  0.000042366

Score:  0.477

Data Source:  BioPlex,STRINGDB

MAPK9

Tchem

Family:  Kinase

Novelty:  0.00267199

p_int:  0.999941428

p_ni:  0.000058572

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (6)

Functions (2)

Components (3)

Processes (1)

Find Similar Targets

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1 – 2 of 2

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (3)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
cleft lip	EFO_0003959	1	1	0	1.2	55.2
Cleft palate	HP_0000175	1	1	0	1.2	55.2
electrocardiography	EFO_0004327	1	1	2		5.3

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
cleft lip	EFO_0003959	0	1.2	55.2
Cleft palate	HP_0000175	0	1.2	55.2
electrocardiography	EFO_0004327	2		5.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Coiled coil
Complete proteome
Metal-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
cleft lip
Cleft palate
electrocardiography

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	zinc finger C3H1-type containing	VGNC:10082	452077
Macaque	zinc finger C3H1-type containing		718671
Mouse	zinc finger, C3H1-type containing	MGI:2446143	216345
Rat	zinc finger, C3H1-type containing	RGD:1306287	314836
Dog	zinc finger C3H1-type containing	VGNC:48605	474449

Species	Name	OMA	EggNOG	Inparanoid
Chimp	zinc finger C3H1-type containing
Macaque	zinc finger C3H1-type containing
Mouse	zinc finger, C3H1-type containing
Rat	zinc finger, C3H1-type containing
Dog	zinc finger C3H1-type containing

Publication Statistics

PubMed Score 7.43

PubMed score by year

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PubTator Score 2.50

PubTator score by year

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Related Publications

Text Mined References (9)

GeneRif Annotations (3)

Items per page:

10

0 of 0

PMID	Year	Title