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Tbio
ZFC3H1
Zinc finger C3H1 domain-containing protein

Protein Summary
Description
Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378743
  • ENSP00000368017
  • ENSG00000133858
  • ENST00000548100
  • ENSP00000450044
  • ENST00000552994
  • ENSP00000446995

Symbol
  • CCDC131
  • KIAA0546
  • PSRC2
  • CSRC2
  • PSRC2
  • CCDC131
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
transcription factor binding site profile
0.92
histone modification site profile
0.85
virus perturbation
0.76
cell type or tissue
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.43   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.43   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (147)
MPHOSPH6
Tbio
Family:  Enzyme
Novelty:  0.24387167
p_int:  0.999999922
p_ni:  7.7e-8
Score:  0.931
Data Source:  BioPlex,STRINGDB
BUB3
Tbio
Novelty:  0.00714143
p_int:  0.999999854
p_ni:  1.46e-7
Score:  0.28
Data Source:  BioPlex,STRINGDB
SMYD2
Tchem
Family:  Epigenetic
Novelty:  0.0192516
p_int:  0.999999501
p_ni:  4.99e-7
Score:  0.227
Data Source:  BioPlex,STRINGDB
CARNMT1
Tbio
Family:  Enzyme
Novelty:  0.28121779
p_int:  0.999999105
p_ni:  8.95e-7
Data Source:  BioPlex
TBC1D1
Tbio
Novelty:  0.0122464
p_int:  0.999998777
p_ni:  5e-9
p_wrong:  0.000001218
Score:  0.251
Data Source:  BioPlex,STRINGDB
EXOSC7
Tbio
Family:  Enzyme
Novelty:  0.07422851
p_int:  0.999975959
p_ni:  0.000024041
Score:  0.951
Data Source:  BioPlex,STRINGDB
SLBP
Tbio
Novelty:  0.00685735
p_int:  0.999973154
p_ni:  0.000013797
p_wrong:  0.000013048
Score:  0.244
Data Source:  BioPlex,STRINGDB
SUFU
Tbio
Novelty:  0.00475249
p_int:  0.999966145
p_ni:  0.000033855
Data Source:  BioPlex
PAPOLG
Tbio
Family:  Enzyme
Novelty:  0.02468251
p_int:  0.999957634
p_ni:  0.000042366
Score:  0.477
Data Source:  BioPlex,STRINGDB
MAPK9
Tchem
Family:  Kinase
Novelty:  0.00267199
p_int:  0.999941428
p_ni:  0.000058572
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
55.2
Cleft palate
1
1
0
1.2
55.2
electrocardiography
1
1
2
5.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
55.2
Cleft palate
0
1.2
55.2
electrocardiography
2
5.3
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger C3H1-type containing
VGNC:10082
452077
Macaque
zinc finger C3H1-type containing
718671
Mouse
MGI:2446143
216345
Rat
RGD:1306287
314836
Dog
zinc finger C3H1-type containing
VGNC:48605
474449
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger C3H1-type containing
Macaque
zinc finger C3H1-type containing
Mouse
Rat
Dog
zinc finger C3H1-type containing
Publication Statistics
PubMed Score 7.43
PubMed score by year
PubTator Score 2.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title