Tbio ZFC3H1 Zinc finger C3H1 domain-containing protein

Protein Summary

Description

Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters.

Uniprot Accession IDs

• O60293
• Q6GMU1
• Q6P2S9
• Q6ZV36
• Q96BE7

Gene Name

• ZFC3H1

Ensembl ID

• ENST00000378743
• ENSP00000368017
• ENSG00000133858
• ENST00000548100
• ENSP00000450044
• ENST00000552994
• ENSP00000446995

Symbol

• CCDC131
• KIAA0546
• PSRC2
• CSRC2
• PSRC2
• CCDC131

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	1
transcription factor binding site profile	0.92
histone modification site profile	0.85
virus perturbation	0.76
cell type or tissue	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.46   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 54   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.46   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0