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Tbio
ZFAND2B
AN1-type zinc finger protein 2B

Protein Summary
Description
Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). This gene encodes a protein containing AN1-type zinc-fingers and ubiquitin-interacting motifs. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000289528
  • ENSP00000289528
  • ENSG00000158552
  • ENST00000409206
  • ENSP00000386824
  • ENST00000409336
  • ENSP00000386898
  • ENST00000409594
  • ENSP00000386399
  • ENST00000444522
  • ENSP00000411334

Symbol
  • AIRAPL
  • AIRAPL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.77
transcription factor binding site profile
0.65
transcription factor
0.62
cell line
0.58
kinase perturbation
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.33   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.33   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
ASB7
Tdark
Novelty:  0.21883348
p_int:  0.999988918
p_ni:  0.000003799
p_wrong:  0.000007283
Score:  0.157
Data Source:  BioPlex,STRINGDB
ATG9A
Tbio
Novelty:  0.01995033
p_int:  0.99995997
p_ni:  0.000015486
p_wrong:  0.000024543
Data Source:  BioPlex
TMC7
Tdark
Family:  IC
Novelty:  0.36769179
p_int:  0.999030726
p_ni:  0.000243932
p_wrong:  0.000725342
Score:  0.243
Data Source:  BioPlex,STRINGDB
ZFYVE27
Tbio
Novelty:  0.0563358
p_int:  0.99878178
p_ni:  0.00027096
p_wrong:  0.000947259
Data Source:  BioPlex
UBB
Tbio
Novelty:  0.00661254
p_int:  0.993233548
p_ni:  0.006766452
Score:  0.569
Data Source:  BioPlex,STRINGDB
PSMC5
Tbio
Family:  Enzyme
Novelty:  0.01634039
p_int:  0.978109089
p_ni:  0.021890911
Score:  0.666
Data Source:  BioPlex,STRINGDB
PSMC6
Tbio
Family:  Enzyme
Novelty:  0.00168013
p_int:  0.96966441
p_ni:  0.03033559
Score:  0.717
Data Source:  BioPlex,STRINGDB
RAD50
Tbio
Novelty:  0.02161298
p_int:  0.955650791
p_ni:  0.044349209
Score:  0.179
Data Source:  BioPlex,STRINGDB
GLUL
Tchem
Family:  Enzyme
Novelty:  0.00086054
p_int:  0.940934685
p_ni:  0.059065315
Score:  0.19
Data Source:  BioPlex,STRINGDB
PAAF1
Tbio
Family:  Enzyme
Novelty:  0.03229774
p_int:  0.931586616
p_ni:  0.068413375
p_wrong:  8e-9
Score:  0.884
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
3
8
95.7
reticulocyte measurement
3
2
5
92.7
body height
2
2
3
92.4
vitamin C measurement
1
1
1
79.9
mean reticulocyte volume
1
2
2
77.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
8
95.7
reticulocyte measurement
5
92.7
body height
3
92.4
vitamin C measurement
1
79.9
mean reticulocyte volume
2
77.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger AN1-type containing 2B
VGNC:3883
743126
Macaque
zinc finger AN1-type containing 2B
702027
Mouse
MGI:1916068
68818
Rat
RGD:1306260
363253
Dog
zinc finger AN1-type containing 2B
VGNC:48601
610602
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger AN1-type containing 2B
Macaque
zinc finger AN1-type containing 2B
Mouse
Rat
Dog
zinc finger AN1-type containing 2B
Publication Statistics
PubMed Score 4.33
PubMed score by year
PubTator Score 6.00
PubTator score by year
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Related Publications
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PMID
Year
Title