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Tbio
ZEB1
Zinc finger E-box-binding homeobox 1

Protein Summary
Description
Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been descr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320985
  • ENSP00000319248
  • ENSG00000148516
  • ENST00000361642
  • ENSP00000354487
  • ENST00000446923
  • ENSP00000391612
  • ENST00000542815
  • ENSP00000444891
  • ENST00000560721
  • ENSP00000452787

Symbol
  • AREB6
  • TCF8
  • BZP
  • TCF8
  • AREB6
  • FECD6
  • NIL2A
  • PPCD3
  • ZFHEP
  • ZFHX1A
  • DELTAEF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
biological process
0.97
biological term
0.95
microRNA
0.91
molecular function
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1297.02   (req: < 5)
Gene RIFs: 352   (req: <= 3)
Antibodies: 633   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1297.02   (req: >= 5)
Gene RIFs: 352   (req: > 3)
Antibodies: 633   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (228)
CTBP1
Tbio
Novelty:  0.00243818
p_int:  1
Score:  0.987
Data Source:  BioPlex,STRINGDB
DCAF15
Tdark
Novelty:  0.13476661
p_int:  0.999999966
p_ni:  3.4e-8
Score:  0.297
Data Source:  BioPlex,STRINGDB
CDH1
Tbio
Novelty:  0.00010629
Score:  0.997
Data Source:  STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.977
Data Source:  STRINGDB
STAT6
Tchem
Family:  TF
Novelty:  0.00096732
Score:  0.92
Data Source:  STRINGDB
SUMO1
Tbio
Novelty:  0.00137629
Score:  0.915
Data Source:  STRINGDB
TWIST1
Tbio
Family:  TF
Novelty:  0.0013639
Score:  0.854
Data Source:  STRINGDB
SMAD3
Tchem
Family:  TF
Novelty:  0.00048058
Score:  0.853
Data Source:  STRINGDB
TP53BP1
Tbio
Family:  Epigenetic
Novelty:  0.00131256
Score:  0.849
Data Source:  STRINGDB
CDH2
Tbio
Novelty:  0.00040112
Score:  0.847
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-4 and Interleukin-13 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-4 and Interleukin-13 signaling
Signaling by Interleukins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (35)
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Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
33.1
mathematical ability
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
33.1
mathematical ability
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger E-box binding homeobox 1
VGNC:7869
450387
Macaque
zinc finger E-box binding homeobox 1
701157
Mouse
MGI:1344313
21417
Rat
RGD:3831
25705
Dog
zinc finger E-box binding homeobox 1
VGNC:48596
477966
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger E-box binding homeobox 1
Macaque
zinc finger E-box binding homeobox 1
Mouse
Rat
Dog
zinc finger E-box binding homeobox 1
Publication Statistics
PubMed Score 1297.02
PubMed score by year
PubTator Score 583.35
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title