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Tbio
ZDHHC9
Palmitoyltransferase ZDHHC9

Protein Summary
Description
The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS. This gene encodes an integral membrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein forms a complex with golgin subfamily A member 7 and functions as a palmitoyltransferase. This protein specifically palmitoylates HRAS and NRAS. Mutations in this gene are associated with X-linked cognitive disability. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357166
  • ENSP00000349689
  • ENSG00000188706
  • ENST00000371064
  • ENSP00000360103

Symbol
  • CXorf11
  • ZDHHC10
  • ZNF379
  • ZNF380
  • CGI89
  • DHHC9
  • MMSA1
  • MRXSZ
  • ZNF379
  • ZNF380
  • CXorf11
  • ZDHHC10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
tissue
0.68
cellular component
0.67
microRNA
0.66
small molecule perturbation
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.84   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.84   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
GDPD5
Tbio
Family:  Enzyme
Novelty:  0.05871733
p_int:  0.994920956
p_ni:  0.005078993
p_wrong:  5.1e-8
Data Source:  BioPlex
LRRC55
Tbio
Family:  IC
Novelty:  0.25121277
p_int:  0.992342518
p_ni:  0.007654607
p_wrong:  0.000002874
Data Source:  BioPlex
TSPAN5
Tbio
Novelty:  0.08879443
p_int:  0.988425529
p_ni:  0.011574425
p_wrong:  4.6e-8
Data Source:  BioPlex
CHRNA9
Tchem
Family:  IC
Novelty:  0.05009815
p_int:  0.988212901
p_ni:  0.011787082
p_wrong:  1.7e-8
Data Source:  BioPlex
GPR21
Tdark
Family:  GPCR
Novelty:  0.90865557
p_int:  0.971412996
p_ni:  0.011234768
p_wrong:  0.017352235
Score:  0.152
Data Source:  BioPlex,STRINGDB
PCDHGA5
Tdark
Novelty:  2.13631603
p_int:  0.961465447
p_ni:  0.023310962
p_wrong:  0.015223591
Data Source:  BioPlex
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  0.956066292
p_ni:  0.043933665
p_wrong:  4.3e-8
Data Source:  BioPlex
TSPAN3
Tbio
Novelty:  0.06362133
p_int:  0.945783262
p_ni:  0.053468597
p_wrong:  0.000748141
Score:  0.209
Data Source:  BioPlex,STRINGDB
NKAIN1
Tdark
Family:  Enzyme
Novelty:  0.52190272
p_int:  0.941228198
p_ni:  0.058732985
p_wrong:  0.000038817
Data Source:  BioPlex
SYNE4
Tbio
Novelty:  0.0739848
p_int:  0.940875904
p_ni:  0.053334552
p_wrong:  0.005789544
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
48.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
48.3
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
zinc finger DHHC-type containing 9
702206
Mouse
MGI:2444393
208884
Rat
RGD:1561389
302808
Dog
zinc finger DHHC-type containing 9
VGNC:48595
492126
Horse
zinc finger DHHC-type containing 9
VGNC:25205
100054679
Species
Name
OMA
EggNOG
Inparanoid
Macaque
zinc finger DHHC-type containing 9
Mouse
Rat
Dog
zinc finger DHHC-type containing 9
Horse
zinc finger DHHC-type containing 9
Publication Statistics
PubMed Score 22.84
PubMed score by year
PubTator Score 15.22
PubTator score by year
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Related Publications
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PMID
Year
Title