You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ZDHHC8
Probable palmitoyltransferase ZDHHC8

Protein Summary
Description
Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1. This gene encodes a four transmembrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein may function as a palmitoyltransferase. Defects in this gene may be associated with a susceptibility to schizophrenia. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 22.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320602
  • ENSP00000317804
  • ENSG00000099904
  • ENST00000334554
  • ENSP00000334490
  • ENST00000405930
  • ENSP00000384716

Symbol
  • KIAA1292
  • ZDHHCL1
  • ZNF378
  • DHHC8
  • ZNF378
  • ZDHHCL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.68
histone modification site profile
0.68
transcription factor perturbation
0.68
cell line
0.64
cell type or tissue
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.2   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.2   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0