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Tbio
ZDHHC8
Probable palmitoyltransferase ZDHHC8

Protein Summary
Description
Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1. This gene encodes a four transmembrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein may function as a palmitoyltransferase. Defects in this gene may be associated with a susceptibility to schizophrenia. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 22.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320602
  • ENSP00000317804
  • ENSG00000099904
  • ENST00000334554
  • ENSP00000334490
  • ENST00000405930
  • ENSP00000384716

Symbol
  • KIAA1292
  • ZDHHCL1
  • ZNF378
  • DHHC8
  • ZNF378
  • ZDHHCL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.68
histone modification site profile
0.68
transcription factor perturbation
0.68
cell line
0.64
cell type or tissue
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.92   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.92   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
CLDND1
Tbio
Novelty:  0.06681793
p_int:  0.999999974
p_wrong:  2.6e-8
Score:  0.269
Data Source:  BioPlex,STRINGDB
ABCA1
Tclin
Family:  Transporter
Novelty:  0.00059241
Score:  0.905
Data Source:  Reactome,STRINGDB
PRODH
Tbio
Family:  Enzyme
Novelty:  0.00315806
Score:  0.795
Data Source:  STRINGDB
TRMT2A
Tbio
Family:  Enzyme
Novelty:  0.15277091
Score:  0.782
Data Source:  STRINGDB
UFD1
Tbio
Novelty:  0.01230296
Score:  0.722
Data Source:  STRINGDB
MRPL40
Tbio
Novelty:  0.09916967
Score:  0.715
Data Source:  STRINGDB
DGCR2
Tbio
Novelty:  0.05838132
Score:  0.679
Data Source:  STRINGDB
COMT
Tclin
Family:  Enzyme
Novelty:  0.00025107
Score:  0.676
Data Source:  STRINGDB
TMEM25
Tdark
Novelty:  0.35505784
Score:  0.676
Data Source:  STRINGDB
RANBP1
Tbio
Family:  Enzyme
Novelty:  0.01208948
Score:  0.668
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
HDL assembly (R-HSA-8963896)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
HDL assembly
Reactome
Plasma lipoprotein assembly
Reactome
Plasma lipoprotein assembly, remodeling, and clearance
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
HDL assembly
Plasma lipoprotein assembly
Plasma lipoprotein assembly, remodeling, and clearance
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
2
4
68.8
serum metabolite measurement
1
1
1
57.8
triglyceride measurement
1
1
1
21.5
body height
1
1
1
21.5
smoking status measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
68.8
serum metabolite measurement
1
57.8
triglyceride measurement
1
21.5
body height
1
21.5
smoking status measurement
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger DHHC-type containing 8
VGNC:7807
458662
Macaque
zinc finger DHHC-type containing 8
712832
Mouse
MGI:1338012
27801
Rat
RGD:1308875
303796
Dog
zinc finger DHHC-type containing 8
VGNC:48594
486415
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger DHHC-type containing 8
Macaque
zinc finger DHHC-type containing 8
Mouse
Rat
Dog
zinc finger DHHC-type containing 8
Publication Statistics
PubMed Score 28.92
PubMed score by year
PubTator Score 15.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title