Tbio ZDHHC7 Palmitoyltransferase ZDHHC7

Protein Summary

Description

Palmitoyltransferase with broad specificity (PubMed:22031296, PubMed:28196865). Palmitoylates JAM3 (PubMed:28196865). Palmitoylates SNAP25 and DLG4/PSD95 (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones (PubMed:22031296). May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (By similarity).

Uniprot Accession IDs

• Q9NXF8
• D3DUM1
• Q8WV42
• Q9NVD8

Gene Name

• ZDHHC7

Ensembl ID

• ENST00000313732
• ENSP00000315604
• ENSG00000153786
• ENST00000344861
• ENSP00000341681
• ENST00000564466
• ENSP00000456782

Symbol

• DHHC7
• SERZ1
• SERZ-B
• ZNF370

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.94
kinase perturbation	0.88
histone modification site profile	0.81
transcription factor binding site profile	0.78
cell type or tissue	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.82   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 131   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.82   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0