Tbio ZDHHC7 Palmitoyltransferase ZDHHC7

Protein Summary

Description

Palmitoyltransferase with broad specificity (PubMed:22031296, PubMed:28196865). Palmitoylates JAM3 (PubMed:28196865). Palmitoylates SNAP25 and DLG4/PSD95 (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones (PubMed:22031296). May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (By similarity).

Uniprot Accession IDs

• Q9NXF8
• D3DUM1
• Q8WV42
• Q9NVD8

Gene Name

• ZDHHC7

Ensembl ID

• ENST00000313732
• ENSP00000315604
• ENSG00000153786
• ENST00000344861
• ENSP00000341681
• ENST00000564466
• ENSP00000456782

Symbol

• DHHC7
• SERZ1
• SERZ-B
• ZNF370

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.94
kinase perturbation	0.88
histone modification site profile	0.81
transcription factor binding site profile	0.78
cell type or tissue	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.74   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 131   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.74   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (24)

Explore Interacting Targets

1 – 10 of 24

• See Interactions on String-DB

CKM

Tbio

Family:  Kinase

Novelty:  0.00239628

p_int:  0.999969068

p_ni:  0.00003092

p_wrong:  1.1e-8

Score:  0.219

Data Source:  BioPlex,STRINGDB

TSPAN31

Tbio

Novelty:  0.13580467

p_int:  0.996900902

p_ni:  1.01e-7

p_wrong:  0.003098997

Data Source:  BioPlex

MARCH6

Tbio

Family:  Enzyme

Novelty:  0.01818691

p_int:  0.992353542

p_ni:  0.000138148

p_wrong:  0.00750831

Score:  0.324

Data Source:  BioPlex,STRINGDB

TMEM186

Tdark

Novelty:  0.59951294

p_int:  0.947196019

p_ni:  0.052803981

Score:  0.214

Data Source:  BioPlex,STRINGDB

NDFIP1

Tbio

Novelty:  0.04496467

p_int:  0.763166908

p_ni:  0.236832657

p_wrong:  4.34e-7

Score:  0.189

Data Source:  BioPlex,STRINGDB

CYB5B

Tbio

Novelty:  0.09395308

Score:  0.665

Data Source:  STRINGDB

ABHD13

Tdark

Family:  Enzyme

Novelty:  2.01646617

Score:  0.601

Data Source:  STRINGDB

SDR42E1

Tdark

Family:  Enzyme

Novelty:  2.41213299

Score:  0.594

Data Source:  STRINGDB

GOLGA7

Tbio

Novelty:  0.17108842

Score:  0.573

Data Source:  STRINGDB

PBX2

Tbio

Family:  TF

Novelty:  0.01339291

Score:  0.565

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (4)

ESR-mediated signaling (R-HSA-8939211)

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1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	ESR-mediated signaling	189 targets	R-HSA-8939211
Reactome	Extra-nuclear estrogen signaling	74 targets	R-HSA-9009391
Reactome	Signal Transduction	2704 targets	R-HSA-162582
Reactome	Signaling by Nuclear Receptors	232 targets	R-HSA-9006931

Name	Explore in Pharos	Explore in Source
ESR-mediated signaling	189 targets	R-HSA-8939211
Extra-nuclear estrogen signaling	74 targets	R-HSA-9009391
Signal Transduction	2704 targets	R-HSA-162582
Signaling by Nuclear Receptors	232 targets	R-HSA-9006931

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (9)

Functions (2)

Components (4)

Processes (3)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
palmitoyltransferase activity	Inferred from Direct Assay (IDA)	UniProtKB
protein-cysteine S-palmitoyltransferase activity	Inferred from Direct Assay (IDA)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (3)

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1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Abdominal Aortic Aneurysm	EFO_0004214	1	1	0	1.1	17.8
body height	EFO_0004339	1	1	1		6.2
BMI-adjusted waist circumference	EFO_0007789	1	1	1		4.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Abdominal Aortic Aneurysm	EFO_0004214	0	1.1	17.8
body height	EFO_0004339	1		6.2
BMI-adjusted waist circumference	EFO_0007789	1		4.2

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UniProt Keyword Find Similar Targets

No Header	No Header
Acyltransferase
Alternative splicing
Complete proteome
Golgi apparatus
Lipoprotein
Membrane
Palmitate
Polymorphism
Reference proteome
Transferase

GWAS Trait Find Similar Targets

No Header	No Header
Abdominal Aortic Aneurysm
BMI-adjusted waist circumference
body height

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	zinc finger DHHC-type containing 7	VGNC:9205	454390
Macaque	zinc finger DHHC-type containing 7		718634
Mouse	zinc finger, DHHC domain containing 7	MGI:2142662	102193
Rat	zinc finger, DHHC-type containing 7	RGD:620205	170906
Dog	zinc finger DHHC-type containing 7	VGNC:48593	489676

Species	Name	OMA	EggNOG	Inparanoid
Chimp	zinc finger DHHC-type containing 7
Macaque	zinc finger DHHC-type containing 7
Mouse	zinc finger, DHHC domain containing 7
Rat	zinc finger, DHHC-type containing 7
Dog	zinc finger DHHC-type containing 7

Publication Statistics

PubMed Score 12.74

PubMed score by year

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PubTator Score 9.73

PubTator score by year

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Related Publications

Text Mined References (15)

GeneRif Annotations (4)

Items per page:

10

0 of 0

PMID	Year	Title