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Tbio
ZDHHC5
Palmitoyltransferase ZDHHC5

Protein Summary
Description
Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5. Also palmitoylates FLOT2 (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287169
  • ENSP00000287169
  • ENSG00000156599
  • ENST00000527985
  • ENSP00000432202

Symbol
  • KIAA1748
  • ZNF375
  • DHHC5
  • ZNF375
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.87
ligand (protein) perturbation
0.83
transcription factor
0.74
virus perturbation
0.68
tissue sample
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.47   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.47   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
CLDND1
Tbio
Novelty:  0.06681793
p_int:  0.999999979
p_ni:  6e-9
p_wrong:  1.5e-8
Score:  0.812
Data Source:  BioPlex,STRINGDB
GOLGA7B
Tdark
Novelty:  1.09326611
p_int:  0.999999944
p_ni:  5.4e-8
p_wrong:  2e-9
Score:  0.526
Data Source:  BioPlex,STRINGDB
HAVCR2
Tbio
Novelty:  0.00155885
p_int:  0.999998269
p_ni:  0.000001731
Score:  0.181
Data Source:  BioPlex,STRINGDB
TMEFF1
Tbio
Novelty:  0.11856207
p_int:  0.99997695
p_ni:  0.000023047
p_wrong:  3e-9
Score:  0.692
Data Source:  BioPlex,STRINGDB
GPR21
Tdark
Family:  GPCR
Novelty:  0.90865557
p_int:  0.999216953
p_ni:  0.000761759
p_wrong:  0.000021288
Score:  0.166
Data Source:  BioPlex,STRINGDB
COQ9
Tbio
Novelty:  0.00740475
Score:  0.676
Data Source:  STRINGDB
UBE2N
Tchem
Novelty:  0.00620946
Score:  0.652
Data Source:  STRINGDB
LRRC8A
Tbio
Novelty:  0.0163093
Score:  0.629
Data Source:  STRINGDB
FXYD1
Tbio
Family:  IC
Novelty:  0.00421639
Score:  0.615
Data Source:  STRINGDB
FLOT2
Tbio
Novelty:  0.00727325
Score:  0.605
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
84.1
mathematical ability
1
1
1
81
neuroticism measurement
5
5
3
6.2
78.2
mean corpuscular hemoglobin concentration
1
1
1
75.2
wellbeing measurement
3
3
3
73.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
84.1
mathematical ability
1
81
neuroticism measurement
3
6.2
78.2
mean corpuscular hemoglobin concentration
1
75.2
wellbeing measurement
3
73.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger DHHC-type containing 5
VGNC:53191
451199
Mouse
MGI:1923573
228136
Rat
RGD:1589737
362156
Horse
zinc finger DHHC-type containing 5
VGNC:25201
100066506
Cow
zinc finger DHHC-type containing 5
VGNC:37143
533250
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger DHHC-type containing 5
Mouse
Rat
Horse
zinc finger DHHC-type containing 5
Cow
zinc finger DHHC-type containing 5
Publication Statistics
PubMed Score 23.47
PubMed score by year
PubTator Score 7.69
PubTator score by year
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Related Publications
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PMID
Year
Title