Tbio ZDHHC20 Palmitoyltransferase ZDHHC20

Protein Summary

Description

Catalyzes palmitoylation of Cys residues on target proteins (PubMed:27153536, PubMed:29326245). Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the duration of EGFR signaling by modulating palmitoylation-dependent EGFR internalization and degradation (PubMed:27153536). Has a preference for acyl-CoA with C16 fatty acid chains (PubMed:29326245). Can also utilize acyl-CoA with C14 and C18 fatty acid chains (PubMed:29326245).

Uniprot Accession IDs

• Q5W0Z9
• A8MTV9
• C9JG20
• I6L9D4
• Q2TB82
• Q6NVU8

Gene Name

• ZDHHC20

Ensembl ID

• ENST00000320220
• ENSP00000313583
• ENSG00000180776
• ENST00000382466
• ENSP00000371905
• ENST00000400590
• ENSP00000383433
• ENST00000415724
• ENSP00000401232

Symbol

• DHHC20
• DHHC-20
• 4933421L13Rik

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.79
histone modification site profile	0.66
tissue sample	0.64
small molecule perturbation	0.63
microRNA	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.99   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 176   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.99   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0