You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
ZDHHC18
Palmitoyltransferase ZDHHC18

Protein Summary
Description
Has palmitoyltransferase activity towards HRAS and LCK.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374141
  • ENSP00000363256
  • ENSG00000204160
  • ENST00000374142
  • ENSP00000363257

Symbol
  • DHHC18
  • DHHC-18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
gene perturbation
0.62
small molecule perturbation
0.59
tissue
0.58
transcription factor binding site profile
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.92   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.92   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (47)
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  0.99744793
p_ni:  0.002552067
p_wrong:  2e-9
Data Source:  BioPlex
SLC34A2
Tchem
Family:  Transporter
Novelty:  0.00601743
p_int:  0.99650613
p_ni:  0.003493843
p_wrong:  2.8e-8
Data Source:  BioPlex
TNFRSF10C
Tbio
Novelty:  0.0088942
p_int:  0.994942706
p_ni:  0.004281157
p_wrong:  0.000776137
Data Source:  BioPlex
LRRC55
Tbio
Family:  IC
Novelty:  0.25121277
p_int:  0.994754814
p_ni:  0.005244468
p_wrong:  7.17e-7
Data Source:  BioPlex
PCDHAC2
Tdark
Novelty:  0.28397695
p_int:  0.993364168
p_ni:  0.00520927
p_wrong:  0.001426563
Data Source:  BioPlex
DLK2
Tbio
Novelty:  0.06366405
p_int:  0.991455774
p_ni:  0.007855815
p_wrong:  0.000688411
Data Source:  BioPlex
LPAR1
Tchem
Family:  GPCR
Novelty:  0.00318056
p_int:  0.975278931
p_ni:  0.024464388
p_wrong:  0.000256681
Score:  0.152
Data Source:  BioPlex,STRINGDB
GPM6A
Tbio
Novelty:  0.04123799
p_int:  0.946266597
p_ni:  0.032159516
p_wrong:  0.021573887
Score:  0.156
Data Source:  BioPlex,STRINGDB
GDPD5
Tbio
Family:  Enzyme
Novelty:  0.05871733
p_int:  0.935905108
p_ni:  0.043978494
p_wrong:  0.020116398
Data Source:  BioPlex
IL13RA2
Tbio
Novelty:  0.03465642
p_int:  0.933551864
p_ni:  0.02566338
p_wrong:  0.040784756
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
2
2
90.4
apolipoprotein A 1 measurement
2
2
2
89.6
C-reactive protein measurement
2
1
3
83.1
serum gamma-glutamyl transferase measurement
2
2
2
78.7
high density lipoprotein cholesterol measurement
4
2
5
78.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
90.4
apolipoprotein A 1 measurement
2
89.6
C-reactive protein measurement
3
83.1
serum gamma-glutamyl transferase measurement
2
78.7
high density lipoprotein cholesterol measurement
5
78.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:3527792
503610
Rat
RGD:1309334
362613
Dog
zinc finger DHHC-type containing 18
VGNC:48584
478172
Horse
zinc finger DHHC-type containing 18
VGNC:25193
100071031
Cow
zinc finger DHHC-type containing 18
VGNC:37133
100337343
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
zinc finger DHHC-type containing 18
Horse
zinc finger DHHC-type containing 18
Cow
zinc finger DHHC-type containing 18
Publication Statistics
PubMed Score 1.92
PubMed score by year
PubTator Score 0.50
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title