Tbio ZDHHC17 Palmitoyltransferase ZDHHC17

Protein Summary

Description

Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT (PubMed:15603740, PubMed:15489887, PubMed:19139280, PubMed:28757145). May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane (PubMed:12393793). May play a role in Mg(2+) transport (PubMed:18794299).

Uniprot Accession IDs

• Q8IUH5
• B4DR39
• O75407
• Q7Z2I0
• Q86W89
• Q86YK0
• Q9P088
• Q9UPZ8

Gene Name

• ZDHHC17

Ensembl ID

• ENST00000426126
• ENSP00000403397
• ENSG00000186908

Symbol

• HIP14
• HIP3
• HYPH
• KIAA0946
• HIP3
• HYPH
• HIP14
• DHHC-17
• HSPC294

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.91
histone modification site profile	0.84
transcription factor binding site profile	0.82
cellular component	0.66
microRNA	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.6   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 181   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.6   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (3)

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (91)

Explore Interacting Targets

1 – 10 of 91

• See Interactions on String-DB

ARSE

Tbio

Family:  Enzyme

Novelty:  0.00151862

p_int:  0.999613396

p_ni:  0.000386604

Data Source:  BioPlex

LPAR1

Tchem

Family:  GPCR

Novelty:  0.00318056

p_int:  0.999439639

p_ni:  0.000560355

p_wrong:  5e-9

Data Source:  BioPlex

PLSCR4

Tbio

Family:  Enzyme

Novelty:  0.12079798

p_int:  0.998592935

p_ni:  0.001407065

Score:  0.252

Data Source:  BioPlex,STRINGDB

DHX57

Tdark

Family:  Enzyme

Novelty:  0.8244078

p_int:  0.998509241

p_ni:  0.001490759

Data Source:  BioPlex

PLAC8L1

Tdark

Novelty:  2.10744169

p_int:  0.998335283

p_ni:  0.001664716

Score:  0.551

Data Source:  BioPlex,STRINGDB

C3AR1

Tchem

Family:  GPCR

Novelty:  0.00527301

p_int:  0.998156909

p_ni:  0.001843091

Data Source:  BioPlex

IPPK

Tbio

Family:  Enzyme

Novelty:  0.02169701

p_int:  0.998145351

p_ni:  0.001854649

Data Source:  BioPlex

AOPEP

Tbio

Family:  Enzyme

Novelty:  0.03344862

p_int:  0.989136232

p_ni:  0.010858975

p_wrong:  0.000004793

Score:  0.199

Data Source:  BioPlex,STRINGDB

TNFRSF19

Tbio

Novelty:  0.01295599

p_int:  0.986981251

p_ni:  0.013018749

Score:  0.518

Data Source:  BioPlex,STRINGDB

FAM135B

Tbio

Novelty:  0.19852891

p_int:  0.977444823

p_ni:  0.022555177

Score:  0.527

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

PathwayCommons (1)

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5

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Data Source	Name	Explore in Pharos	Explore in Source
PathwayCommons: netpath	TCR	258 targets	PathwayCommons: netpath

Name	Explore in Pharos	Explore in Source
TCR	258 targets	PathwayCommons: netpath

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (16)

Functions (4)

Components (9)

Processes (3)

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10

1 – 4 of 4

GO Term	Evidence	Assigned by
magnesium ion transmembrane transporter activity	Inferred from Direct Assay (IDA)	UniProtKB
palmitoyltransferase activity	Inferred from Direct Assay (IDA)	UniProtKB
protein-cysteine S-palmitoyltransferase activity	Inferred from Direct Assay (IDA)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct

Disease Associations (null)

No disease associations found

GWAS Traits (0)

No GWAS traits found

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acyltransferase
Alternative splicing
ANK repeat
Cell junction
Cell membrane
Complete proteome
Cytoplasmic vesicle
Golgi apparatus
Lipoprotein

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cellular phenotype
growth/size/body region phenotype
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	zinc finger DHHC-type containing 17	VGNC:8614	452088
Macaque	zinc finger DHHC-type containing 17		693595
Mouse	zinc finger, DHHC domain containing 17	MGI:2445110	320150
Rat	zinc finger, DHHC-type containing 17	RGD:1595790	366889
Dog	zinc finger DHHC-type containing 17	VGNC:48583	482574

Species	Name	OMA	EggNOG	Inparanoid
Chimp	zinc finger DHHC-type containing 17
Macaque	zinc finger DHHC-type containing 17
Mouse	zinc finger, DHHC domain containing 17
Rat	zinc finger, DHHC-type containing 17
Dog	zinc finger DHHC-type containing 17

Publication Statistics

PubMed Score 37.60

PubMed score by year

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PubTator Score 17.42

PubTator score by year

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Related Publications

Text Mined References (30)

GeneRif Annotations (17)

Items per page:

10

0 of 0

PMID	Year	Title