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Tbio
ZDHHC16
Palmitoyltransferase ZDHHC16

Protein Summary
Description
Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6 (PubMed:28826475). Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization (By similarity). Also required for eye development (By similarity). Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function (PubMed:28826475). May play a role in DNA damage response (By similarity). May be involved in apoptosis regulation (By similarity). Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345745
  • ENSP00000304487
  • ENSG00000171307
  • ENST00000352634
  • ENSP00000345383
  • ENST00000353979
  • ENSP00000323360
  • ENST00000370842
  • ENSP00000359879
  • ENST00000370854
  • ENSP00000359891
  • ENST00000393760
  • ENSP00000377357

Symbol
  • APH2
  • APH2
  • DHHC-16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
histone modification site profile
0.89
disease perturbation
0.68
virus perturbation
0.68
transcription factor binding site profile
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.19   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.19   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
CRYAA
Tchem
Novelty:  0.01914081
p_int:  0.999913753
p_ni:  7.11e-7
p_wrong:  0.000085536
Data Source:  BioPlex
PGP
Tbio
Family:  Enzyme
Novelty:  0.0225528
Score:  0.735
Data Source:  STRINGDB
ABL1
Tclin
Family:  Kinase
Novelty:  0.00023803
Score:  0.722
Data Source:  STRINGDB
CYB5B
Tbio
Novelty:  0.09395308
Score:  0.719
Data Source:  STRINGDB
B4GALT4
Tbio
Family:  Enzyme
Novelty:  0.11226614
Score:  0.683
Data Source:  STRINGDB
LYPLA1
Tchem
Family:  Enzyme
Novelty:  0.01217068
Score:  0.642
Data Source:  STRINGDB
PIGV
Tbio
Family:  Enzyme
Novelty:  0.05672936
Score:  0.628
Data Source:  STRINGDB
DNLZ
Tdark
Novelty:  0.10113346
Score:  0.626
Data Source:  STRINGDB
LZIC
Tdark
Novelty:  0.34151594
Score:  0.608
Data Source:  STRINGDB
LYPLA2
Tchem
Family:  Enzyme
Novelty:  0.05436006
Score:  0.605
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
3
3
3
95.9
monocyte percentage of leukocytes
2
2
2
90.7
granulocyte percentage of myeloid white cells
1
1
1
40.7
leukocyte count
1
1
1
21.3
BMI-adjusted waist circumference
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
3
95.9
monocyte percentage of leukocytes
2
90.7
granulocyte percentage of myeloid white cells
1
40.7
leukocyte count
1
21.3
BMI-adjusted waist circumference
1
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger DHHC-type containing 16
VGNC:7867
450652
Macaque
zinc finger DHHC-type containing 16
705982
Mouse
MGI:1921418
74168
Rat
RGD:1591893
654495
Dog
zinc finger DHHC-type containing 16
VGNC:48582
486820
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger DHHC-type containing 16
Macaque
zinc finger DHHC-type containing 16
Mouse
Rat
Dog
zinc finger DHHC-type containing 16
Publication Statistics
PubMed Score 5.19
PubMed score by year
PubTator Score 19.12
PubTator score by year
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Related Publications
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PMID
Year
Title