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Tdark
ZDHHC1
Probable palmitoyltransferase ZDHHC1

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348579
  • ENSP00000340299
  • ENSG00000159714

Symbol
  • C16orf1
  • ZNF377
  • DHHC-1
  • ZNF377
  • C16orf1
  • HSU90653
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.78
molecular function
0.67
tissue sample
0.64
transcription factor
0.64
transcription factor binding site profile
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.93   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.93   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (15)
PIK3CA
Tclin
Family:  Kinase
Novelty:  0.00044273
p_int:  0.979993357
p_ni:  0.019467887
p_wrong:  0.000538756
Score:  0.199
Data Source:  BioPlex,STRINGDB
TAOK2
Tchem
Family:  Kinase
Novelty:  0.0232708
p_int:  0.968138565
p_ni:  0.03186124
p_wrong:  1.95e-7
Score:  0.275
Data Source:  BioPlex,STRINGDB
LGR4
Tbio
Family:  GPCR
Novelty:  0.01180123
p_int:  0.965315184
p_ni:  0.034684815
p_wrong:  1e-9
Data Source:  BioPlex
PIK3CB
Tchem
Family:  Kinase
Novelty:  0.00390277
p_int:  0.860006104
p_ni:  0.139993896
Score:  0.177
Data Source:  BioPlex,STRINGDB
DDI2
Tbio
Novelty:  0.09288646
p_int:  0.826631882
p_ni:  0.173368118
Score:  0.211
Data Source:  BioPlex,STRINGDB
MTA2
Tbio
Family:  TF
Novelty:  0.01525806
p_int:  0.813716542
p_ni:  0.186283458
Score:  0.165
Data Source:  BioPlex,STRINGDB
LRRC29
Tdark
Novelty:  1.92387854
Score:  0.584
Data Source:  STRINGDB
KLHL32
Tdark
Novelty:  0.6299831
Score:  0.495
Data Source:  STRINGDB
GFOD2
Tdark
Family:  Enzyme
Novelty:  0.45929342
Score:  0.489
Data Source:  STRINGDB
SPRYD7
Tdark
Novelty:  0.25334319
Score:  0.456
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
6
4
10
78
mean corpuscular volume
1
1
1
71.9
mean reticulocyte volume
1
1
1
71.6
comparative body size at age 10, self-reported
1
1
1
66.3
BMI-adjusted waist circumference
4
2
5
57.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
10
78
mean corpuscular volume
1
71.9
mean reticulocyte volume
1
71.6
comparative body size at age 10, self-reported
1
66.3
BMI-adjusted waist circumference
5
57.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger DHHC-type containing 1
VGNC:9204
454165
Macaque
zinc finger DHHC-type containing 1
697969
Mouse
MGI:1918046
70796
Rat
RGD:1589775
291967
Dog
zinc finger DHHC-type containing 1
VGNC:48577
479686
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger DHHC-type containing 1
Macaque
zinc finger DHHC-type containing 1
Mouse
Rat
Dog
zinc finger DHHC-type containing 1
Publication Statistics
PubMed Score 3.93
PubMed score by year
PubTator Score 0.79
PubTator score by year
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Related Publications
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PMID
Year
Title