You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
ZDBF2
DBF4-type zinc finger-containing protein 2

Protein Summary
Description
This gene encodes a protein containing DBF4-type zinc finger domains. This gene is imprinted and paternally expressed in lymphocytes but is more stochastically expressed in the placenta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374423
  • ENSP00000363545
  • ENSG00000204186
  • ENST00000636761
  • ENSP00000490610
  • ENSG00000283649
  • ENST00000649650
  • ENSP00000497308
  • ENST00000649768
  • ENSP00000498089

Symbol
  • KIAA1571
  • Slx9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.88
virus perturbation
0.76
tissue sample
0.73
cell line
0.7
cell type or tissue
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.2   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 14   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.2   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
BCAS2
Tbio
Novelty:  0.05425016
p_int:  0.999999798
p_ni:  2.01e-7
Data Source:  BioPlex
PRPF19
Tbio
Novelty:  0.01616737
p_int:  0.999998526
p_ni:  1.1e-7
p_wrong:  0.000001364
Data Source:  BioPlex
CSNK1A1
Tchem
Family:  Kinase
Novelty:  0.00636472
p_int:  0.9999828
p_ni:  0.000017059
p_wrong:  1.41e-7
Data Source:  BioPlex
VAPB
Tbio
Novelty:  0.00542377
p_int:  0.999918145
p_ni:  0.000081853
p_wrong:  1e-9
Score:  0.19
Data Source:  BioPlex,STRINGDB
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.999742919
p_ni:  0.00025708
p_wrong:  1e-9
Data Source:  BioPlex
CPNE2
Tdark
Novelty:  0.24188419
p_int:  0.99957908
p_ni:  0.000420919
p_wrong:  1e-9
Data Source:  BioPlex
SENP6
Tchem
Family:  Enzyme
Novelty:  0.00776149
p_int:  0.999486909
p_ni:  0.000513063
p_wrong:  2.8e-8
Score:  0.822
Data Source:  BioPlex,STRINGDB
RPL28
Tbio
Novelty:  0.03136035
p_int:  0.99864301
p_ni:  0.001356988
p_wrong:  1e-9
Data Source:  BioPlex
SET
Tbio
Novelty:  0.01012327
p_int:  0.998439921
p_ni:  0.001560078
p_wrong:  1e-9
Score:  0.239
Data Source:  BioPlex,STRINGDB
SIRT6
Tchem
Family:  Epigenetic
Novelty:  0.00155366
p_int:  0.996955833
p_ni:  0.003021254
p_wrong:  0.000022913
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
1
1
83.2
comparative body size at age 10, self-reported
1
1
1
83.2
body mass index
6
3
6
69.2
body mass index
6
3
6
69.2
mean corpuscular volume
1
1
1
35
Items per page:
1 – 5 of 8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
83.2
comparative body size at age 10, self-reported
1
83.2
body mass index
6
69.2
body mass index
6
69.2
mean corpuscular volume
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger DBF-type containing 2
VGNC:3881
470622
Mouse
MGI:1921134
73884
Rat
RGD:1560005
501153
Dog
zinc finger DBF-type containing 2
VGNC:48576
488490
Cow
zinc finger DBF-type containing 2 [Source:HGNC Symbol;Acc:HGNC:29313]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger DBF-type containing 2
Mouse
Rat
Dog
zinc finger DBF-type containing 2
Cow
zinc finger DBF-type containing 2 [Source:HGNC Symbol;Acc:HGNC:29313]
Publication Statistics
PubMed Score 7.20
PubMed score by year
PubTator Score 3.71
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title