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Tdark
ZCRB1
Zinc finger CCHC-type and RNA-binding motif-containing protein 1

Protein Summary
Description
Pre-mRNA splicing is catalyzed by the spliceosome. U12-type spliceosome binds U12-type pre-mRNAs and recognizes the 5' splice site and branch-point sequence. U11 and U12 snRNPs are components of U12-type spliceosome and function as a molecular bridge connecting both ends of the intron. The protein encoded by this gene contains a RNA recognition motif. It was identified as one of the protein components of U11/U12 snRNPs. This protein and many other U11/U12 snRNP proteins are highly conserved in organisms known to contain U12-type introns. These proteins have been shown to be essential for cell viability, suggesting the key roles in U12-type splicing. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266529
  • ENSP00000266529
  • ENSG00000139168

Symbol
  • MADP1
  • RBM36
  • MADP-1
  • SNRNP31
  • ZCCHC19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
transcription factor perturbation
0.88
transcription factor binding site profile
0.75
small molecule perturbation
0.66
cell line
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.82   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.82   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (151)
ZRSR2
Tbio
Novelty:  0.03449891
p_int:  0.99999995
p_ni:  5e-8
Score:  0.957
Data Source:  BioPlex,STRINGDB
HIST1H1A
Tbio
Novelty:  0.00123818
p_int:  0.999998539
p_ni:  0.000001461
Score:  0.56
Data Source:  BioPlex,STRINGDB
PDCD7
Tbio
Novelty:  0.15531712
p_int:  0.999996948
p_ni:  0.000003047
p_wrong:  6e-9
Score:  0.957
Data Source:  BioPlex,STRINGDB
SNRNP35
Tdark
Novelty:  1.00002211
p_int:  0.999996837
p_ni:  0.000003163
Score:  0.975
Data Source:  BioPlex,STRINGDB
RNPC3
Tbio
Novelty:  0.07154673
p_int:  0.999992285
p_ni:  0.000007715
Score:  0.975
Data Source:  BioPlex,STRINGDB
SNRNP48
Tbio
Novelty:  0.16395917
p_int:  0.999991445
p_ni:  0.000008548
p_wrong:  7e-9
Score:  0.957
Data Source:  BioPlex,STRINGDB
YBX2
Tbio
Family:  TF
Novelty:  0.01540247
p_int:  0.999973713
p_ni:  0.000026286
p_wrong:  1e-9
Score:  0.625
Data Source:  BioPlex,STRINGDB
ZMAT5
Tdark
Novelty:  0.97115324
p_int:  0.999970715
p_ni:  0.000028919
p_wrong:  3.66e-7
Score:  0.946
Data Source:  BioPlex,STRINGDB
ZRSR2P1
Tdark
Novelty:  0.0367357
p_int:  0.999767463
p_ni:  0.00000759
p_wrong:  0.000224946
Score:  0.422
Data Source:  BioPlex,STRINGDB
RPL26L1
Tdark
Novelty:  0.75408617
p_int:  0.997976367
p_ni:  0.002023633
Score:  0.31
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

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Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Minor Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Minor Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
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Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
21.5
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger CCHC-type and RNA binding motif containing 1
VGNC:8613
466960
Macaque
zinc finger CCHC-type and RNA binding motif containing 1
699318
Mouse
MGI:1914447
67197
Rat
RGD:1309851
362990
Dog
zinc finger CCHC-type and RNA binding motif containing 1
VGNC:48574
477640
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger CCHC-type and RNA binding motif containing 1
Macaque
zinc finger CCHC-type and RNA binding motif containing 1
Mouse
Rat
Dog
zinc finger CCHC-type and RNA binding motif containing 1
Publication Statistics
PubMed Score 4.82
PubMed score by year
PubTator Score 2.33
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title