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Tbio
ZC4H2
Zinc finger C4H2 domain-containing protein

Protein Summary
Description
Plays a role in interneurons differentiation (PubMed:26056227). Involved in neuronal development and in neuromuscular junction formation. This gene encodes a member of the zinc finger domain-containing protein family. This family member has a C-terminal zinc finger domain that is characterized by four cysteine residues and two histidine residues, and it also includes a coiled-coil region. This protein has been detected as an autoantigen in hepatocellular carcinoma patients. This gene has been identified as a potential candidate for X-linked cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337990
  • ENSP00000338650
  • ENSG00000126970
  • ENST00000374839
  • ENSP00000363972
  • ENST00000447788
  • ENSP00000399126

Symbol
  • HCA127
  • KIAA1166
  • WWS
  • WRWF
  • MRXS4
  • HCA127
  • KIAA1166
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.65
microRNA
0.63
cell type or tissue
0.56
tissue
0.55
cellular component
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.36   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.36   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
HMG20A
Tbio
Family:  TF
Novelty:  0.11994252
p_int:  0.999999994
p_ni:  3e-9
p_wrong:  3e-9
Score:  0.175
Data Source:  BioPlex,STRINGDB
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.999999991
p_ni:  9e-9
Data Source:  BioPlex
AGGF1
Tbio
Novelty:  0.02757407
p_int:  0.999998175
p_ni:  0.000001825
Score:  0.534
Data Source:  BioPlex,STRINGDB
RNF220
Tbio
Family:  Enzyme
Novelty:  0.14024436
p_int:  0.9999939
p_ni:  5.39e-7
p_wrong:  0.000005561
Score:  0.654
Data Source:  BioPlex,STRINGDB
PMF1
Tbio
Novelty:  0.05319446
p_int:  0.999991724
p_ni:  0.000008186
p_wrong:  9e-8
Data Source:  BioPlex
COLEC12
Tbio
Novelty:  0.02882427
p_int:  0.999989625
p_ni:  0.00000183
p_wrong:  0.000008544
Score:  0.183
Data Source:  BioPlex,STRINGDB
HOOK3
Tbio
Novelty:  0.0553474
p_int:  0.989755949
p_ni:  0.010244051
Score:  0.28
Data Source:  BioPlex,STRINGDB
POMT2
Tbio
Family:  Enzyme
Novelty:  0.0251595
Score:  0.779
Data Source:  STRINGDB
FKRP
Tbio
Novelty:  0.00798137
Score:  0.778
Data Source:  STRINGDB
POMT1
Tbio
Family:  Enzyme
Novelty:  0.01971429
Score:  0.76
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger C4H2-type containing
VGNC:7546
465671
Macaque
zinc finger C4H2-type containing
708764
Mouse
MGI:2679294
245522
Rat
RGD:1561708
367838
Dog
zinc finger C4H2-type containing
VGNC:48564
491920
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger C4H2-type containing
Macaque
zinc finger C4H2-type containing
Mouse
Rat
Dog
zinc finger C4H2-type containing
Publication Statistics
PubMed Score 23.36
PubMed score by year
PubTator Score 5.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title