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Tbio
ZC3HC1
Nuclear-interacting partner of ALK

Protein Summary
Description
Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events. This gene encodes an F-box-containing protein that is a component of an SCF-type E3 ubiquitin ligase complex that regulates the onset of cell division. The G2/M transition in the cell cycle requires the interaction of the proteins cyclin B1 and cyclin-dependent kinase 1. The activated ubiquitin ligase complex targets the protein cyclin B1 for degradation, preventing this transition to mitosis. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311873
  • ENSP00000309301
  • ENSG00000091732
  • ENST00000358303
  • ENSP00000351052
  • ENST00000360708
  • ENSP00000353933

Symbol
  • NIPA
  • NIPA
  • HSPC216
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
kinase
0.89
drug perturbation
0.87
interacting protein
0.74
phenotype
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.31   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.31   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.999999519
p_ni:  4.81e-7
Score:  0.539
Data Source:  BioPlex,STRINGDB
NXF2
Tbio
Novelty:  0.04733504
p_int:  0.999995305
p_ni:  0.000004695
Data Source:  BioPlex
PLK1
Tchem
Family:  Kinase
Novelty:  0.00062799
p_int:  0.999990334
p_ni:  0.000009666
Score:  0.175
Data Source:  BioPlex,STRINGDB
SASS6
Tbio
Novelty:  0.00680548
p_int:  0.999986097
p_ni:  0.000013903
Score:  0.163
Data Source:  BioPlex,STRINGDB
GPX7
Tbio
Family:  Enzyme
Novelty:  0.01342855
p_int:  0.999534765
p_ni:  0.000465235
Data Source:  BioPlex
DCUN1D2
Tchem
Novelty:  1.02957984
p_int:  0.999492546
p_ni:  0.000507394
p_wrong:  6e-8
Data Source:  BioPlex
ANKRD39
Tdark
Novelty:  8.68843298
p_int:  0.999094094
p_ni:  0.000905901
p_wrong:  5e-9
Data Source:  BioPlex
GRN
Tbio
Novelty:  0.00096395
p_int:  0.99787554
p_ni:  0.002115369
p_wrong:  0.000009091
Score:  0.183
Data Source:  BioPlex,STRINGDB
TPR
Tbio
Novelty:  0.00462503
p_int:  0.991915462
p_ni:  0.008084538
Score:  0.407
Data Source:  BioPlex,STRINGDB
ATP6V1C2
Tbio
Family:  Enzyme
Novelty:  0.07583427
p_int:  0.986677137
p_ni:  0.012163394
p_wrong:  0.001159469
Score:  0.171
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1)
Find Similar Targets
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Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
2
2
88.7
platelet crit
2
2
2
84.7
9
1
5
1.1
76.5
myeloid white cell count
1
1
1
72.6
sex hormone-binding globulin measurement
4
1
4
71.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
88.7
platelet crit
2
84.7
5
1.1
76.5
myeloid white cell count
1
72.6
sex hormone-binding globulin measurement
4
71.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger C3HC-type containing 1
VGNC:4568
463722
Macaque
zinc finger C3HC-type containing 1
702173
Mouse
MGI:1916023
232679
Rat
RGD:1561099
296957
Horse
zinc finger C3HC-type containing 1
VGNC:25172
100057013
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger C3HC-type containing 1
Macaque
zinc finger C3HC-type containing 1
Mouse
Rat
Horse
zinc finger C3HC-type containing 1
Publication Statistics
PubMed Score 12.31
PubMed score by year
PubTator Score 51.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title