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Tbio
ZC3H3
Zinc finger CCCH domain-containing protein 3

Protein Summary
Description
Required for the export of polyadenylated mRNAs from the nucleus (PubMed:19364924). Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262577
  • ENSP00000262577
  • ENSG00000014164

Symbol
  • KIAA0150
  • SMICL
  • ZC3HDC3
  • ZC3HDC3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
ligand (protein) perturbation
0.83
transcription factor binding site profile
0.77
cell line
0.75
histone modification site profile
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.97   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.97   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (146)
PABPC3
Tbio
Novelty:  0.13551529
p_int:  1
Score:  0.262
Data Source:  BioPlex,STRINGDB
IKZF5
Tbio
Family:  TF
Novelty:  0.36596327
p_int:  0.999999755
p_ni:  2.41e-7
p_wrong:  4e-9
Data Source:  BioPlex
LTBR
Tbio
Novelty:  0.003823
p_int:  0.999995699
p_ni:  0.000004301
Data Source:  BioPlex
HIST1H1A
Tbio
Novelty:  0.00123818
p_int:  0.999738804
p_ni:  0.000260835
p_wrong:  3.61e-7
Score:  0.277
Data Source:  BioPlex,STRINGDB
HIST1H1C
Tbio
Novelty:  0.00415337
p_int:  0.999605122
p_ni:  0.000394877
p_wrong:  1e-9
Data Source:  BioPlex
MTMR9
Tbio
Novelty:  0.09702778
p_int:  0.998726846
p_ni:  0.001212315
p_wrong:  0.000060839
Data Source:  BioPlex
CACNG5
Tdark
Family:  IC
Novelty:  0.52705448
p_int:  0.997085059
p_ni:  0.00291494
p_wrong:  1e-9
Data Source:  BioPlex
ZNF70
Tdark
Family:  TF
Novelty:  0.51405169
p_int:  0.996629333
p_ni:  0.003370665
p_wrong:  2e-9
Score:  0.225
Data Source:  BioPlex,STRINGDB
RAB3IP
Tbio
Novelty:  0.04046982
p_int:  0.995518162
p_ni:  0.003400711
p_wrong:  0.001081127
Data Source:  BioPlex
RPL36AL
Tbio
Novelty:  0.09336423
p_int:  0.994162825
p_ni:  0.005835387
p_wrong:  0.000001788
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
2
3
92.3
metabolite measurement
1
1
1
82.8
C-reactive protein measurement
2
2
2
75.9
Oral ulcer
1
1
0
1.1
75.4
monocyte count
1
1
1
57.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
92.3
metabolite measurement
1
82.8
C-reactive protein measurement
2
75.9
Oral ulcer
0
1.1
75.4
monocyte count
1
57.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger CCCH-type containing 3
VGNC:761
464443
Mouse
MGI:2663721
223642
Rat
RGD:1307276
300032
Dog
zinc finger CCCH-type containing 3
VGNC:48558
482077
Horse
zinc finger CCCH-type containing 3
VGNC:25168
100065889
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger CCCH-type containing 3
Mouse
Rat
Dog
zinc finger CCCH-type containing 3
Horse
zinc finger CCCH-type containing 3
Publication Statistics
PubMed Score 3.97
PubMed score by year
PubTator Score 0.56
PubTator score by year
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Related Publications
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PMID
Year
Title